Review
Version 1
Preserved in Portico This version is not peer-reviewed
Targeting divergent pathways in the nutritional management of depression
Version 1
: Received: 17 June 2024 / Approved: 18 June 2024 / Online: 18 June 2024 (13:37:09 CEST)
A peer-reviewed article of this Preprint also exists.
Tobin, D.; Vuckovic, A.; Sarris, J. Targeting Divergent Pathways in the Nutritional Management of Depression. Nutrients 2024, 16, 2806. Tobin, D.; Vuckovic, A.; Sarris, J. Targeting Divergent Pathways in the Nutritional Management of Depression. Nutrients 2024, 16, 2806.
Abstract
Nutritional management of depression has long been discussed due to the perceived benefit of a nutritional product having less side effects than pharmaceutical agents. Candidate nutrients for managing depression include Vitamin D, B-vitamins, tryptophan, branch chain amino acids, probiotics, omega-3 fatty acids, folate/methylfolate (aka Vitamin B9), and s-adenosylmethionine.
This paper reviews three nutrients which have significant scientific support for the management of depression and have evidence of low levels in subjects with depression, and that correction of the nutritional deficiency provides clinical benefit. We present epidemiological evidence, mechanistic explanation and a review of interventional studies for these nutrients. Finally, relevant nutritional guidelines are presented with their conclusion for the role of each nutrient in the management of depression.
Keywords
Depression; nutrition; omega-3; EPA; methylfolate; s-adenosylmethionine, SAMe.
Subject
Medicine and Pharmacology, Dietetics and Nutrition
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment