Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Would be Rutin a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems

Maíra Bueno Ariede
,
Wallace Androm Gomez Junior
,
Thalita Marcílio Cândido
ORCID logo ,
Michelle Maria Gonçalves Barão de Aguiar
,
Catarina Rosado
ORCID logo ,
Carlota de Oliveira Rangel-Yagui
ORCID logo ,
Maria Valéria Robles Velasco
ORCID logo ,
André Rolim Baby
* ORCID logo
Version 1 : Received: 18 June 2024 / Approved: 19 June 2024 / Online: 19 June 2024 (11:25:20 CEST)

A peer-reviewed article of this Preprint also exists.

Ariede, M.B.; Gomez Junior, W.A.; Cândido, T.M.; de Aguiar, M.M.G.B.; Rosado, C.; Rangel-Yagui, C. de O.; Pessoa, F.V.L.S.; Velasco, M.V.R.; Baby, A.R. Would Rutin Be a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems. Cosmetics 2024, 11, 141, doi:10.3390/cosmetics11040141. Ariede, M.B.; Gomez Junior, W.A.; Cândido, T.M.; de Aguiar, M.M.G.B.; Rosado, C.; Rangel-Yagui, C. de O.; Pessoa, F.V.L.S.; Velasco, M.V.R.; Baby, A.R. Would Rutin Be a Feasible Strategy for Environmental-Friendly Photoprotective Samples? A Review from Stability to Skin Permeability and Efficacy in Sunscreen Systems. Cosmetics 2024, 11, 141, doi:10.3390/cosmetics11040141.

Abstract

Rutin, a flavonoid compound found in various plants, has gained attention for its potential applications in the cosmetic industry due to its antioxidant, anti-inflammatory, and potential photoprotective properties. Our review explored the use of rutin (rutoside, 3-O-rutinoside-quercetin) in cosmetics/dermocosmetics, focusing on its physicochemical properties and stability, cutaneous permeability, and efficacy in sunscreen systems, involving in vitro tests and the current state of clinical trials. Rutin's ability to scavenge free radicals, prevent peroxidation, and reduce vascular fragility makes this flavonoid a promising ingredient for photoprotection. Studies have shown that rutin can enhance the sun protection factor (SPF) of sunscreen formulations, especially when combined with organic UV filters. The encapsulation of rutin in nanostructures has also been investigated to improve its applicability. Overall, rutin shows potential as a safe and effective ingredient in cosmetic/dermocosmetic formulations, offering protection against the harmful effects of UV radiation and oxidative stress on the skin.

Keywords

rutoside; labsphere; sunscreens; UV filters; sun protection factor

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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