Changes in RANKL, OPG, and 25(OH)D Levels in Children with Leukemia from Diagnosis to Remission

Salvador Atilano-Miguel; Lourdes Barbosa-Cortés; Rocío Ortiz-Muñiz; Jorge Maldonado-Hernández; Jorge A Martin-Trejo; Maricela Rodríguez-Cruz; Lourdes Balcázar-Hernández; Karina A Solís-Labastida; Benito A Bautista-Martínez; Azalia Juárez-Moya; Zayra Hernández-Piñón; Raeline A Galindo-Rodríguez; Adriana Chávez Anaya; Rosa E Valdez-Avilez; Juan M Domínguez-Salgado; Judith Villa-Morales; María E Rodríguez-Palacios

doi:10.20944/preprints202406.1413.v1

How to cite: Atilano-Miguel, S.; Barbosa-Cortés, L.; Ortiz-Muñiz, R.; Maldonado-Hernández, J.; Martin-Trejo, J. A.; Rodríguez-Cruz, M.; Balcázar-Hernández, L.; Solís-Labastida, K. A.; Bautista-Martínez, B. A.; Juárez-Moya, A.; Hernández-Piñón, Z.; Galindo-Rodríguez, R. A.; Chávez Anaya, A.; Valdez-Avilez, R. E.; Domínguez-Salgado, J. M.; Villa-Morales, J.; Rodríguez-Palacios, M. E. Changes in RANKL, OPG, and 25(OH)D Levels in Children with Leukemia from Diagnosis to Remission. Preprints 2024, 2024061413. https://doi.org/10.20944/preprints202406.1413.v1 Atilano-Miguel, S.; Barbosa-Cortés, L.; Ortiz-Muñiz, R.; Maldonado-Hernández, J.; Martin-Trejo, J. A.; Rodríguez-Cruz, M.; Balcázar-Hernández, L.; Solís-Labastida, K. A.; Bautista-Martínez, B. A.; Juárez-Moya, A.; Hernández-Piñón, Z.; Galindo-Rodríguez, R. A.; Chávez Anaya, A.; Valdez-Avilez, R. E.; Domínguez-Salgado, J. M.; Villa-Morales, J.; Rodríguez-Palacios, M. E. Changes in RANKL, OPG, and 25(OH)D Levels in Children with Leukemia from Diagnosis to Remission. Preprints 2024, 2024061413. https://doi.org/10.20944/preprints202406.1413.v1

Abstract

Background: The receptor activator of the nuclear factor-kB (RANK)/RANK ligand (RANKL)/osteoprotegerin (OPG) pathway is a determining pathway in the balance between bone formation and resorption; disruptions in this complex can affect bone metabolism. Methods: This study analyzed the changes in RANKL, OPG and 25(OH)D levels, the RANKL/OPG ratio, and other bone turnover markers (BTM) from diagnosis to complete remission in children with acute lym-phoblastic leukemia (ALL). This is a prospective observational cohort study. This study was carried out in the Instituto Mexicano del Seguro Social in Mexico City. Thirty-three patients (4-17 years) with newly diagnosed B-cell ALL were included. The patients were treated with the HP09 chemotherapy protocol. Children who had previously been treated with corticosteroids were excluded. A pe-ripheral blood sample at diagnosis and remission was collected to determine the 25(OH)D and BTM concentrations. Results: Increased RANKL (p=0.001) and osteocalcin (p

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Changes in RANKL, OPG, and 25(OH)D Levels in Children with Leukemia from Diagnosis to Remission

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