Review
Version 1
Preserved in Portico This version is not peer-reviewed
Hyperuricemia: Current State and Prospects
Version 1
: Received: 20 June 2024 / Approved: 20 June 2024 / Online: 20 June 2024 (15:10:58 CEST)
How to cite: Zhang, W.-Z. Hyperuricemia: Current State and Prospects. Preprints 2024, 2024061458. https://doi.org/10.20944/preprints202406.1458.v1 Zhang, W.-Z. Hyperuricemia: Current State and Prospects. Preprints 2024, 2024061458. https://doi.org/10.20944/preprints202406.1458.v1
Abstract
Hyperuricemia (HU), characterized by elevated uric acid (UA) levels in the blood, represents a global health concern associated with various conditions, including cardiovascular diseases, gout, hypertension, metabolic syndrome, renal dysfunction, and neurodegenerative diseases. This review offers a contemporary analysis of HU, encompassing its causes, associated health risks, diagnosis, treatment, and future outlook. Recent studies have underscored the multifaceted origin of HU, implicating genetic predisposition, dietary patterns, lifestyle choices, and environmental influences. Genetic variations affecting enzymes and transporters involved in purine metabolism and UA excretion have been identified, laying the groundwork for personalized treatment strategies. Advances in diagnostic imaging and omics technologies provide enhanced precision in the detection and evaluation of risks. While pharmacological interventions remain central to managing HU, persistent challenges such as treatment resistance prompt exploration of novel drug targets and lifestyle modifications. Chinese herbal medicines offer a potentially alternative approach with fewer side effects. Emerging research on the impact of gut microbiota on UA metabolism opens new therapeutic avenues. Despite progress, challenges such as optimizing treatment duration and understanding long-term effects persist. Collaborative efforts are crucial to address these challenges and advance our comprehension of HU. The integration of precision medicine and holistic patient care approaches holds promise for improving outcomes and enhancing quality of life for individuals with HU.
Keywords
Hyperuricemia; microbiota; physical activity; caveolae; uric acid metabolism; cardiovascular disease; metabolic syndrome
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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