Version 1
: Received: 20 June 2024 / Approved: 21 June 2024 / Online: 21 June 2024 (10:45:06 CEST)
How to cite:
Ricarte, M.; Tagkalidou, N.; Bellot, M.; Bedrossiantz, J.; Prats, E.; Gomez-Canela, C.; Garcia-Reyero, N.; Raldúa, D. Short- and Long-Term Neurobehavioral Effects of the Developmental Exposure to Valproic Acid in Zebrafish. Preprints2024, 2024061497. https://doi.org/10.20944/preprints202406.1497.v1
Ricarte, M.; Tagkalidou, N.; Bellot, M.; Bedrossiantz, J.; Prats, E.; Gomez-Canela, C.; Garcia-Reyero, N.; Raldúa, D. Short- and Long-Term Neurobehavioral Effects of the Developmental Exposure to Valproic Acid in Zebrafish. Preprints 2024, 2024061497. https://doi.org/10.20944/preprints202406.1497.v1
Ricarte, M.; Tagkalidou, N.; Bellot, M.; Bedrossiantz, J.; Prats, E.; Gomez-Canela, C.; Garcia-Reyero, N.; Raldúa, D. Short- and Long-Term Neurobehavioral Effects of the Developmental Exposure to Valproic Acid in Zebrafish. Preprints2024, 2024061497. https://doi.org/10.20944/preprints202406.1497.v1
APA Style
Ricarte, M., Tagkalidou, N., Bellot, M., Bedrossiantz, J., Prats, E., Gomez-Canela, C., Garcia-Reyero, N., & Raldúa, D. (2024). Short- and Long-Term Neurobehavioral Effects of the Developmental Exposure to Valproic Acid in Zebrafish. Preprints. https://doi.org/10.20944/preprints202406.1497.v1
Chicago/Turabian Style
Ricarte, M., Natalia Garcia-Reyero and Demetrio Raldúa. 2024 "Short- and Long-Term Neurobehavioral Effects of the Developmental Exposure to Valproic Acid in Zebrafish" Preprints. https://doi.org/10.20944/preprints202406.1497.v1
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and restricted interest for specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the development of ASD. Animal models can serve as crucial tools for understanding the complexity of ASD and identifying potential therapeutic strategies. In this study, a chemical model of ASD has been developed in zebrafish by exposing embryos to valproic acid (VPA) from 4 to 48 hours post-fertilization. After the exposure, embryos were transferred to fish water and the effects on behavior and neurotransmitters profile were analyzed at both larval and adult stages. Larvae from VPA-treated embryos showed hyperactivity and decreased visual and vibrational escape responses, as well as an altered neurotransmitters profile, with increased glutamate and decreased acetylcholine and norepinephrine levels. Adults from VPA-treated embryos exhibited impaired social behavior characterized by larger shoal sizes and a decreased interest for their conspecifics. Neurotransmitter analysis revealed a significant decrease in dopamine and GABA levels in the brain. These results support the interest of this model in the study of ASD.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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