Version 1
: Received: 21 June 2024 / Approved: 24 June 2024 / Online: 24 June 2024 (08:43:58 CEST)
How to cite:
Niazi, F.; Parker, K. A.; Mason, S. J.; Singh, S.; Schiemann, W. P.; Valadkhan, S. Induction of Invasive Basal Phenotype in Triple-Negative Breast Cancers by Long Noncoding RNA BORG. Preprints2024, 2024061624. https://doi.org/10.20944/preprints202406.1624.v1
Niazi, F.; Parker, K. A.; Mason, S. J.; Singh, S.; Schiemann, W. P.; Valadkhan, S. Induction of Invasive Basal Phenotype in Triple-Negative Breast Cancers by Long Noncoding RNA BORG. Preprints 2024, 2024061624. https://doi.org/10.20944/preprints202406.1624.v1
Niazi, F.; Parker, K. A.; Mason, S. J.; Singh, S.; Schiemann, W. P.; Valadkhan, S. Induction of Invasive Basal Phenotype in Triple-Negative Breast Cancers by Long Noncoding RNA BORG. Preprints2024, 2024061624. https://doi.org/10.20944/preprints202406.1624.v1
APA Style
Niazi, F., Parker, K. A., Mason, S. J., Singh, S., Schiemann, W. P., & Valadkhan, S. (2024). Induction of Invasive Basal Phenotype in Triple-Negative Breast Cancers by Long Noncoding RNA BORG. Preprints. https://doi.org/10.20944/preprints202406.1624.v1
Chicago/Turabian Style
Niazi, F., William P Schiemann and Saba Valadkhan. 2024 "Induction of Invasive Basal Phenotype in Triple-Negative Breast Cancers by Long Noncoding RNA BORG" Preprints. https://doi.org/10.20944/preprints202406.1624.v1
Abstract
Long noncoding RNAs (lncRNAs) are known to play key roles in breast cancers; however, detailed mechanistic studies of lncRNA function have not been conducted in large cohorts of breast cancer tumors, nor have inter-donor and inter-subtype variabilities been taken into consideration. Here we provide the first identification and annotation of the human BORG lncRNA gene. Using multiple tumor cohorts of human breast cancers, we show that while BORG expression is strongly induced in breast tumors as compared to normal breast tissues, the extent of BORG induction varies widely between breast cancer subtypes and even between different tumors within the same subtype. Elevated levels of BORG in breast tumors are associated with the acquisition of core cancer aggression pathways, including those associated with basal tumor and pluripotency phenotypes, and with epithelial-mesenchymal transition (EMT) programs. While a subset of BORG-associated pathways was present in high BORG-expressing tumors across all breast cancer subtypes, many were specific to triple-negative breast cancer tumors. Finally, we show that genes induced by heterologous expression of BORG in murine models of TNBC both in vitro and in vivo strongly overlap with those associated with high BORG levels in human TNBC tumors, indicating that human BORG is a novel driver of the highly aggressive basal TNBC tumor phenotype.
Keywords
long non-coding RNAs; lncRNAs; TNBC; Cancer stem cells; basal breast cancer; breast cancer
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
