Version 1
: Received: 20 June 2024 / Approved: 24 June 2024 / Online: 24 June 2024 (13:48:40 CEST)
How to cite:
da Nóbrega Borges, J. V.; Abdel Correia Leila, S.; Guedes da Nóbrega Machado, M. COMPARE CABG: A Meta-Analysis of Comparative Outcomes in On-Pump vs. Off-Pump Coronary Artery Bypass Grafting. Preprints2024, 2024061666. https://doi.org/10.20944/preprints202406.1666.v1
da Nóbrega Borges, J. V.; Abdel Correia Leila, S.; Guedes da Nóbrega Machado, M. COMPARE CABG: A Meta-Analysis of Comparative Outcomes in On-Pump vs. Off-Pump Coronary Artery Bypass Grafting. Preprints 2024, 2024061666. https://doi.org/10.20944/preprints202406.1666.v1
da Nóbrega Borges, J. V.; Abdel Correia Leila, S.; Guedes da Nóbrega Machado, M. COMPARE CABG: A Meta-Analysis of Comparative Outcomes in On-Pump vs. Off-Pump Coronary Artery Bypass Grafting. Preprints2024, 2024061666. https://doi.org/10.20944/preprints202406.1666.v1
APA Style
da Nóbrega Borges, J. V., Abdel Correia Leila, S., & Guedes da Nóbrega Machado, M. (2024). COMPARE CABG: A Meta-Analysis of Comparative Outcomes in On-Pump vs. Off-Pump Coronary Artery Bypass Grafting. Preprints. https://doi.org/10.20944/preprints202406.1666.v1
Chicago/Turabian Style
da Nóbrega Borges, J. V., Samira Abdel Correia Leila and Manuella Guedes da Nóbrega Machado. 2024 "COMPARE CABG: A Meta-Analysis of Comparative Outcomes in On-Pump vs. Off-Pump Coronary Artery Bypass Grafting" Preprints. https://doi.org/10.20944/preprints202406.1666.v1
Abstract
Background: Coronary artery bypass grafting (CABG) can be performed using on-pump or off-pump techniques. The optimal approach remains debated. Objectives: The COMPARE CABG (Comparative Outcomes of Mortality, Perioperative complications, cARdiac function, and Hospital stay in On-Pump versus Off-Pump Coronary Artery Bypass Grafting) study aims to systematically compare the outcomes of these surgical approaches. Methods: A comprehensive search was conducted in Pubmed, Cochrane Library, and other databases. Studies with a sample size > 4000 were included. Outcomes analyzed included mortality, complications, cardiac function, and hospital stay. Results: Meta-analysis of 5 studies with 58,232 patients showed that off-pump CABG was associated with a slightly lower complication rate: 15% for on-pump CABG and 13.5% for off-pump CABG with a pooled effect size of 0.90 (95% CI: 0.85-0.95). In terms of cardiac function and hospital stay, results were also favorable to off-pump CABG with an effect size of 1.12 (95% CI: 1.05-1.19) and 1.15 (95% CI: 1.10-1.20), respectively. The pooled mortality rate was 2.5% for on-pump and 2.4% for off-pump CABG, with an effect size of 1.05 (95% CI: 0.98-1.12), indicating no significant difference between the groups. Conclusion: These findings suggest that off-pump CABG may be a preferable option for reducing surgical complications, though both techniques yield comparable mortality outcomes. Further research is needed to explore long-term cardiac function and patient-specific factors influencing the choice of surgical method.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
