Version 1
: Received: 24 June 2024 / Approved: 24 June 2024 / Online: 24 June 2024 (12:03:48 CEST)
How to cite:
Rubio, B.; Pintado, C.; Mazuecos, L.; Benito, M.; Andrés, A.; Gallardo, N. Central Actions of Leptin Induce an Atrophic Pattern and Improves Heart Function in Lean Normoleptinemic Rats via PPARβ/δ Activation. Preprints2024, 2024061683. https://doi.org/10.20944/preprints202406.1683.v1
Rubio, B.; Pintado, C.; Mazuecos, L.; Benito, M.; Andrés, A.; Gallardo, N. Central Actions of Leptin Induce an Atrophic Pattern and Improves Heart Function in Lean Normoleptinemic Rats via PPARβ/δ Activation. Preprints 2024, 2024061683. https://doi.org/10.20944/preprints202406.1683.v1
Rubio, B.; Pintado, C.; Mazuecos, L.; Benito, M.; Andrés, A.; Gallardo, N. Central Actions of Leptin Induce an Atrophic Pattern and Improves Heart Function in Lean Normoleptinemic Rats via PPARβ/δ Activation. Preprints2024, 2024061683. https://doi.org/10.20944/preprints202406.1683.v1
APA Style
Rubio, B., Pintado, C., Mazuecos, L., Benito, M., Andrés, A., & Gallardo, N. (2024). Central Actions of Leptin Induce an Atrophic Pattern and Improves Heart Function in Lean Normoleptinemic Rats via PPARβ/δ Activation. Preprints. https://doi.org/10.20944/preprints202406.1683.v1
Chicago/Turabian Style
Rubio, B., Antonio Andrés and Nilda Gallardo. 2024 "Central Actions of Leptin Induce an Atrophic Pattern and Improves Heart Function in Lean Normoleptinemic Rats via PPARβ/δ Activation" Preprints. https://doi.org/10.20944/preprints202406.1683.v1
Abstract
Leptin, acting centrally or peripherally, has complex effects on cardiac remodeling and heart function. We previously reported that central leptin exerts an anti-hypertrophic effect in the heart via cardiac PPARβ/δ activation. Here, we assessed the impact of central leptin administra-tion and PPARβ/δ inhibition on cardiac function. Various cardiac properties, including QRS du-ration, R wave amplitude, heart rate (HR), ejection fraction (EF), end-diastolic left ventricular mass (EDLVM), end-diastolic volume (EDV), and cardiac output (CO) were analyzed. Central leptin infusion increased cardiac PPARβ/δ protein content and decreased HR, QRS duration and R wave amplitude. These changes induced by central leptin suggested a decrease in the ventricu-lar wall growth which was confirmed by MRI. In fact, the EDLVM was reduced by central leptin, while increased in rats co-treated with leptin and GSK0660, a selective antagonist of PPARβ/δ ac-tivity. In summary, central leptin plays a dual role in cardiac health, potentially leading to ven-tricular atrophy and improving heart function when PPARβ/δ signaling is intact. The protective effects of leptin are lost by PPARβ/δ inhibition, underscoring the importance of this pathway. These findings highlight the therapeutic potential of targeting leptin and PPARβ/δ pathways to combat cardiac alterations and heart failure, particularly, in the context of obesity
Keywords
PPARβ/δ; leptin; MRI; cardiac remodeling; Wistar rat
Subject
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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