Synthesis of 2-Azetidinones via Cycloaddition Approaches: An Update

Franca Maria Cordero; Donatella Giomi; Fabrizio Machetti

doi:10.20944/preprints202406.1800.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 25 June 2024 / Approved: 25 June 2024 / Online: 26 June 2024 (08:06:24 CEST)

The present review is a comprehensive update of the synthesis of monocyclic β-lactams via cycloaddition reactions. According to the IUPAC definition of cycloaddition, both elementary and stepwise processes (formal cycloadditions) have been considered. The years 2019-2022 are covered by the cited literature. The focus of the review is on synthetic aspects with emphasis on the structural scope, reaction conditions, mechanistic aspects, and selectivity results. Selected significant data related to biological activities and synthetic applications are also highlighted.

2-azetidinone; β-lactam; cycloaddition; ketene; imine; isocyanate; nitrone.

Chemistry and Materials Science, Organic Chemistry

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Synthesis of 2-Azetidinones via Cycloaddition Approaches: An Update

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