Version 1
: Received: 27 June 2024 / Approved: 28 June 2024 / Online: 29 June 2024 (06:14:53 CEST)
How to cite:
Torres-Vanegas, J.; Rodriguez-Echevarria, R.; Campos-Perez, W.; Rodriguez-Reyes, C.; Reyes-Perez, S.; Perez-Robles, M.; Martinez-Lopez, E. Effect of Omega 3 Fatty Acids on Inflammation Resolution in Pa-Tients with Obesity: A Randomized Placebo-Controlled Trial. Preprints2024, 2024062041. https://doi.org/10.20944/preprints202406.2041.v1
Torres-Vanegas, J.; Rodriguez-Echevarria, R.; Campos-Perez, W.; Rodriguez-Reyes, C.; Reyes-Perez, S.; Perez-Robles, M.; Martinez-Lopez, E. Effect of Omega 3 Fatty Acids on Inflammation Resolution in Pa-Tients with Obesity: A Randomized Placebo-Controlled Trial. Preprints 2024, 2024062041. https://doi.org/10.20944/preprints202406.2041.v1
Torres-Vanegas, J.; Rodriguez-Echevarria, R.; Campos-Perez, W.; Rodriguez-Reyes, C.; Reyes-Perez, S.; Perez-Robles, M.; Martinez-Lopez, E. Effect of Omega 3 Fatty Acids on Inflammation Resolution in Pa-Tients with Obesity: A Randomized Placebo-Controlled Trial. Preprints2024, 2024062041. https://doi.org/10.20944/preprints202406.2041.v1
APA Style
Torres-Vanegas, J., Rodriguez-Echevarria, R., Campos-Perez, W., Rodriguez-Reyes, C., Reyes-Perez, S., Perez-Robles, M., & Martinez-Lopez, E. (2024). Effect of Omega 3 Fatty Acids on Inflammation Resolution in Pa-Tients with Obesity: A Randomized Placebo-Controlled Trial. Preprints. https://doi.org/10.20944/preprints202406.2041.v1
Chicago/Turabian Style
Torres-Vanegas, J., Mariana Perez-Robles and Erika Martinez-Lopez. 2024 "Effect of Omega 3 Fatty Acids on Inflammation Resolution in Pa-Tients with Obesity: A Randomized Placebo-Controlled Trial" Preprints. https://doi.org/10.20944/preprints202406.2041.v1
Abstract
Obesity is associated with chronic low-grade inflammation. Polyunsaturated fatty ac-ids such as omega-3 (n-3), are essential in the pro-resolution of inflammation. An 8-week double-blind randomized clinical trial was conducted with a n-6:n-3, 5:1 ratio, along with daily 1.8 g of n-3 supplementation vs. placebo. A total of 40 subjects were included, 21 in omega 3 group and 19 in placebo group. The n-3 supplementation had a superior effect compared to placebo increasing levels of Resolvin D1 [129.3 (-90.1 - 193.5) vs. -16.8 (-237.8 - 92.5) pg/mL, p=0.041], IL-10 [1.4 (-0.7 - 4.6) vs. -2.0 (-5 - 0.05) pg/mL, p=0.001], and decreasing IL-6 [-0.67 (2.72 - -0.59) vs. 0.03 (-0.59 - 1.84) pg/mL p=0.015], and MCP-1 [-29.6 (-94.9 - 5.50) vs. 18.3 (-97.3 - 66.35) pg/mL, p=0.040]. In con-clusion, n-3 supplementation promoted resolution of inflammation by increasing sys-temic levels of Resolvin D1, IL-10, and decreasing IL-6 and MCP-1.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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