Version 1
: Received: 30 June 2024 / Approved: 1 July 2024 / Online: 1 July 2024 (15:01:59 CEST)
How to cite:
Ryzhkov, A. I.; Sokolova, S. Y.; Vasilyeva, A. E.; Shormanov, I. S. Relationship Between Serum Concentration of Sex Hormone Binding Globulin, Age, and Testosterone Levels in Men. Preprints2024, 2024070063. https://doi.org/10.20944/preprints202407.0063.v1
Ryzhkov, A. I.; Sokolova, S. Y.; Vasilyeva, A. E.; Shormanov, I. S. Relationship Between Serum Concentration of Sex Hormone Binding Globulin, Age, and Testosterone Levels in Men. Preprints 2024, 2024070063. https://doi.org/10.20944/preprints202407.0063.v1
Ryzhkov, A. I.; Sokolova, S. Y.; Vasilyeva, A. E.; Shormanov, I. S. Relationship Between Serum Concentration of Sex Hormone Binding Globulin, Age, and Testosterone Levels in Men. Preprints2024, 2024070063. https://doi.org/10.20944/preprints202407.0063.v1
APA Style
Ryzhkov, A. I., Sokolova, S. Y., Vasilyeva, A. E., & Shormanov, I. S. (2024). Relationship Between Serum Concentration of Sex Hormone Binding Globulin, Age, and Testosterone Levels in Men. Preprints. https://doi.org/10.20944/preprints202407.0063.v1
Chicago/Turabian Style
Ryzhkov, A. I., Alexandra Evgenievna Vasilyeva and Igor Sergeevich Shormanov. 2024 "Relationship Between Serum Concentration of Sex Hormone Binding Globulin, Age, and Testosterone Levels in Men" Preprints. https://doi.org/10.20944/preprints202407.0063.v1
Abstract
Background/Objectives: An age-associated increase in serum levels of sex hormone binding globulin (SHBG) is considered to be one of the factors leading to the development of male hy-pogonadism. Aim of the study: to study the relationship between the concentration of sex hor-mone-binding globulin in the blood serum and the age of the man, the level of total and free testosterone. A single-center retrospective cross-sectional study was conducted. The results of laboratory tests of 162 male patients aged from 18 to 56 years (median - 34 years) were analyzed. Methods: The level of total testosterone and sex hormone binding globulin (SHBG) was deter-mined by chemiluminescent immunoassay. The level of free testosterone was determined by the calculation method according to Vermeullen. Statistical analysis was performed using SPSS Sta-tistics v23. Results: Correlation analysis did not reveal a significant relationship between age and SHBG levels, as well as between age and total testosterone levels. Serum SHBG concentration showed a significant (p
Keywords
sex hormone binding globulin; SHBG; male hypogonadism; free testosterone
Subject
Medicine and Pharmacology, Urology and Nephrology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
