Version 1
: Received: 1 July 2024 / Approved: 2 July 2024 / Online: 2 July 2024 (10:08:13 CEST)
How to cite:
Liu, Y.; Yuan, Y.; He, J.; Han, S.; Liu, Y. Iodophor/H2O2 Mediated 2-Sulfonylation of Indoles and N-Methylpyrrole in Aqueous Phase. Preprints2024, 2024070182. https://doi.org/10.20944/preprints202407.0182.v1
Liu, Y.; Yuan, Y.; He, J.; Han, S.; Liu, Y. Iodophor/H2O2 Mediated 2-Sulfonylation of Indoles and N-Methylpyrrole in Aqueous Phase. Preprints 2024, 2024070182. https://doi.org/10.20944/preprints202407.0182.v1
Liu, Y.; Yuan, Y.; He, J.; Han, S.; Liu, Y. Iodophor/H2O2 Mediated 2-Sulfonylation of Indoles and N-Methylpyrrole in Aqueous Phase. Preprints2024, 2024070182. https://doi.org/10.20944/preprints202407.0182.v1
APA Style
Liu, Y., Yuan, Y., He, J., Han, S., & Liu, Y. (2024). Iodophor/H<sub>2</sub>O<sub>2</sub> Mediated 2-Sulfonylation of Indoles and N-Methylpyrrole in Aqueous Phase. Preprints. https://doi.org/10.20944/preprints202407.0182.v1
Chicago/Turabian Style
Liu, Y., Sheng Han and Yan Liu. 2024 "Iodophor/H<sub>2</sub>O<sub>2</sub> Mediated 2-Sulfonylation of Indoles and N-Methylpyrrole in Aqueous Phase" Preprints. https://doi.org/10.20944/preprints202407.0182.v1
Abstract
A convenient and efficient strategy for the preparation of 2-sulfonylindoles has been achieved through iodophor/H2O2-mediated 2-sulfonylation of indoles with readily available sulfonyl hydrazides in aqueous phase. Iodophor is commercially available and serves as the green catalyst and aqueous phase. A series of 2-sulfonylated products from indoles and N-methylpyrrole were synthesized in moderate yields in only 10 min. Control experiments were also conducted to reveal the mechanism. This method is environment friendly, easy to operate and suitable for a wide range of substrates.
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
