Version 1
: Received: 3 July 2024 / Approved: 3 July 2024 / Online: 3 July 2024 (11:42:27 CEST)
How to cite:
Wolf, D.; Ayon-Olivas, M.; Sendtner, M. BDNF-Regulated Modulation of Striatal Circuits and Implications for Neurological Diseases. Preprints2024, 2024070328. https://doi.org/10.20944/preprints202407.0328.v1
Wolf, D.; Ayon-Olivas, M.; Sendtner, M. BDNF-Regulated Modulation of Striatal Circuits and Implications for Neurological Diseases. Preprints 2024, 2024070328. https://doi.org/10.20944/preprints202407.0328.v1
Wolf, D.; Ayon-Olivas, M.; Sendtner, M. BDNF-Regulated Modulation of Striatal Circuits and Implications for Neurological Diseases. Preprints2024, 2024070328. https://doi.org/10.20944/preprints202407.0328.v1
APA Style
Wolf, D., Ayon-Olivas, M., & Sendtner, M. (2024). BDNF-Regulated Modulation of Striatal Circuits and Implications for Neurological Diseases. Preprints. https://doi.org/10.20944/preprints202407.0328.v1
Chicago/Turabian Style
Wolf, D., Maurilyn Ayon-Olivas and Michael Sendtner. 2024 "BDNF-Regulated Modulation of Striatal Circuits and Implications for Neurological Diseases" Preprints. https://doi.org/10.20944/preprints202407.0328.v1
Abstract
Neurotrophins, particularly brain-derived neurotrophic factor (BDNF), act as key regulators of neuronal development, survival and plasticity. In this review, we focus on the role of BDNF for corticostriatal plasticity in movement disorders, including Parkinson’s Disease (PD) and dystonia. We discuss the mechanisms how dopaminergic input modulates BDNF/TrkB signaling at corticostriatal synapses and the involvement of these mechanisms in neuronal function and synaptic plasticity. Disruption of these pathways can lead to aberrant plasticity, ultimately affecting motor function. Advancing our understanding of these mechanisms could pave the way towards innovative therapeutic strategies aiming at restoring neuroplasticity and enhancing motor function in these diseases.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
