Version 1
: Received: 3 July 2024 / Approved: 3 July 2024 / Online: 4 July 2024 (02:58:59 CEST)
How to cite:
Trendafilova, I.; Popova, M. Porous Silica Nanomaterials as Carriers of Biologically Active Natural Polyphenols: Effect of Structure and Surface Modification. Preprints2024, 2024070343. https://doi.org/10.20944/preprints202407.0343.v1
Trendafilova, I.; Popova, M. Porous Silica Nanomaterials as Carriers of Biologically Active Natural Polyphenols: Effect of Structure and Surface Modification. Preprints 2024, 2024070343. https://doi.org/10.20944/preprints202407.0343.v1
Trendafilova, I.; Popova, M. Porous Silica Nanomaterials as Carriers of Biologically Active Natural Polyphenols: Effect of Structure and Surface Modification. Preprints2024, 2024070343. https://doi.org/10.20944/preprints202407.0343.v1
APA Style
Trendafilova, I., & Popova, M. (2024). Porous Silica Nanomaterials as Carriers of Biologically Active Natural Polyphenols: Effect of Structure and Surface Modification. Preprints. https://doi.org/10.20944/preprints202407.0343.v1
Chicago/Turabian Style
Trendafilova, I. and Margarita Popova. 2024 "Porous Silica Nanomaterials as Carriers of Biologically Active Natural Polyphenols: Effect of Structure and Surface Modification" Preprints. https://doi.org/10.20944/preprints202407.0343.v1
Abstract
For centuries, humans have relied on natural products to prevent and treat numerous health issues. However, biologically active compounds from natural sources, such as polyphenols, face significant challenges, including low solubility, rapid metabolism, and instability, which hinder their effectiveness. Advances in science and nanotechnology have provided solutions to overcoming these problems through the use of porous silica materials. These materials possess unique properties, such as a high specific surface area, adjustable particle and pore sizes, and a surface that can be easily and selectively modified. In this review, we summarize and discuss findings on how the pore and particle size, structure, and surface modification of silica materials influence the preparation of efficient delivery systems for biologically active polyphenols from natural sources. The available data demonstrate how parameters such as adsorption capacity, release and antioxidant properties, bioavailability, solubility, stability, etc. of the studied delivery systems could be affected by the structural and chemical characteristics of the porous silica carriers.
Keywords
porous silica; drug delivery; surface modification; natural bioactive compounds; polyphenols
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
