Preprint Review Version 1 This version is not peer-reviewed

Endoscopic Management of Strictures in Crohn’s Disease: An Unsolved Case

Version 1 : Received: 3 July 2024 / Approved: 4 July 2024 / Online: 4 July 2024 (11:01:33 CEST)

How to cite: Coppola, G.; Principessa, C.; Di Vincenzo, F.; Puca, P.; Del Gaudio, A.; Capobianco, I.; Bartocci, B.; Papa, A.; Cammarota, G.; Lopetuso, L. R.; Scaldaferri, F. Endoscopic Management of Strictures in Crohn’s Disease: An Unsolved Case. Preprints 2024, 2024070424. https://doi.org/10.20944/preprints202407.0424.v1 Coppola, G.; Principessa, C.; Di Vincenzo, F.; Puca, P.; Del Gaudio, A.; Capobianco, I.; Bartocci, B.; Papa, A.; Cammarota, G.; Lopetuso, L. R.; Scaldaferri, F. Endoscopic Management of Strictures in Crohn’s Disease: An Unsolved Case. Preprints 2024, 2024070424. https://doi.org/10.20944/preprints202407.0424.v1

Abstract

Crohn’s disease (CD) is a chronic inflammatory disease associated with a significant burden in terms of quality of life and health care costs and is frequently associated with several complications, including the development of intestinal strictures. Stricturing CD requires a careful multidisciplinary approach involving medical therapy and surgery, still posing a continuous management challenge; in this context, endoscopic treatment represents a valuable, in-between opportunity as a minimally invasive strategy, endorsed by extensive yet heterogeneous evidence and evolving research and techniques. This review summarizes current knowledge on the role of therapeutic endoscopy in stricturing CD, focusing on evidence gaps, recent updates, and novel techniques intended for optimizing efficacy, safety, and tailoring of this approach in the view of precision endoscopy.

Keywords

Crohn’s Disease; Crohn; stricture; balloon dilation; EBD; stricturotomy; intestinal stent; fibrosis; nanoparticles

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

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