Preprint Article Version 1 This version is not peer-reviewed

A Retrospective Cross-Sectional Analysis of Self-Reported Adverse Events Following Immunization with the Shingrix Vaccine  

Version 1 : Received: 27 June 2024 / Approved: 1 July 2024 / Online: 5 July 2024 (09:17:29 CEST)

How to cite: Khalid, A.; Wons, M.; Vaghela, A.; Hollar, S.; Mack, J.; Evans, H.; Snyder, J.; Brooks, B. A Retrospective Cross-Sectional Analysis of Self-Reported Adverse Events Following Immunization with the Shingrix Vaccine  . Preprints 2024, 2024070502. https://doi.org/10.20944/preprints202407.0502.v1 Khalid, A.; Wons, M.; Vaghela, A.; Hollar, S.; Mack, J.; Evans, H.; Snyder, J.; Brooks, B. A Retrospective Cross-Sectional Analysis of Self-Reported Adverse Events Following Immunization with the Shingrix Vaccine  . Preprints 2024, 2024070502. https://doi.org/10.20944/preprints202407.0502.v1

Abstract

This paper investigates the safety profile of the Shingrix vaccine, focusing particularly on persistent adverse events post-vaccination. Shingrix, crucial for preventing shingles caused by the varicella-zoster virus, has shown efficacy in clinical trials but is associated with varying degrees of adverse reactions. This retrospective, cross-sectional survey-based study, spanning two years and involving 77 respondents who experienced severe adverse events after vaccination, reveals a spectrum of symptoms ranging from mild to severe, including reports of Guillain-Barré syndrome and neuropathy. These findings underscore the need for ongoing vigilance in vaccine safety monitoring and highlight the importance of personalized care approaches for managing post-vaccination adverse effects. The study aims to contribute to informed decision-making regarding shingles vaccination strategies and calls for continued research into the long-term safety and efficacy of Shingrix.

Keywords

Shingrix vaccine, herpes zoster, shingles, vaccination, adverse events, immunization, public health.

Subject

Medicine and Pharmacology, Medicine and Pharmacology

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