PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia
Version 1
: Received: 8 July 2024 / Approved: 8 July 2024 / Online: 9 July 2024 (08:14:29 CEST)
How to cite:
Radić, J.; Nikolić, I.; Kolarov-Bjelobrk, I.; Vasiljević, T.; Djurić, A. D.; Vidović, V.; Kožik, B. Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia. Preprints2024, 2024070666. https://doi.org/10.20944/preprints202407.0666.v1
Radić, J.; Nikolić, I.; Kolarov-Bjelobrk, I.; Vasiljević, T.; Djurić, A. D.; Vidović, V.; Kožik, B. Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia. Preprints 2024, 2024070666. https://doi.org/10.20944/preprints202407.0666.v1
Radić, J.; Nikolić, I.; Kolarov-Bjelobrk, I.; Vasiljević, T.; Djurić, A. D.; Vidović, V.; Kožik, B. Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia. Preprints2024, 2024070666. https://doi.org/10.20944/preprints202407.0666.v1
APA Style
Radić, J., Nikolić, I., Kolarov-Bjelobrk, I., Vasiljević, T., Djurić, A. D., Vidović, V., & Kožik, B. (2024). Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia. Preprints. https://doi.org/10.20944/preprints202407.0666.v1
Chicago/Turabian Style
Radić, J., Vladimir Vidović and Bojana Kožik. 2024 "Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia" Preprints. https://doi.org/10.20944/preprints202407.0666.v1
Abstract
The treatment of patients with metastatic colorectal cancer (mCRC) is complex and impacted by the location of the primary tumor (LPT). Our study aims to emphasize the importance of LPT as a prognostic and predictive marker, as well as to examine the significance of HER2 overexpression in patients with mCRC, particularly in relation to response to anti-EGFR therapy. In this study, 181 patients with KRAS wild-type mCRC who received anti-EGFR therapy were included. Among them, 101 had left colon cancer (LCC) and 80 had right colon cancer (RCC). Results demonstrated that patients with KRAS wild-type LCC had better median overall survival (OS) (43 vs. 33 months, p = 0.005) and progression-free survival (PFS) (6 vs. 3 months, p < 0.001) compared to those with RCC. Multivariate analysis identified mucinous adenocarcinoma (p < 0.001), RCC location (p = 0.022), perineural invasions (p = 0.034), and tumors at the resection margin (p = 0.001) as independent predictors of OS, while mucinous adenocarcinoma (p = 0.001) and RCC location (p = 0.004) independently correlated with significantly shorter PFS. In addition, HER2 positive expression was significantly associated with worse PFS compared to HER2 negative results (p < 0.001). In conclusion, LPT is an important marker for predicting outcomes in the treatment of wild-type mCRC using anti-EGFR therapy, since patients with RCC have a statistically significantly shorter PFS and OS. Further investigation is needed to understand the role of HER2 overexpression in wild-type mCRC, as these patients also exhibit shorter survival.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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