PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Fructose-Based Metal Organic Framework as a Means to Synthesize Chitosan Nanospheres Loaded with Sr with NLO Properties for Theranostic Applications in Radiotherapy
Version 1
: Received: 8 July 2024 / Approved: 8 July 2024 / Online: 9 July 2024 (05:45:36 CEST)
How to cite:
Cioci, A.; Benzi, P.; Canepa, C.; Mortati, L.; Alvarez de la Paz, A.; Garnica-Palafox, I. M.; Sánchez‑Arévalo, F. M.; Dante, R. C.; Marabello, D. Fructose-Based Metal Organic Framework as a Means to Synthesize Chitosan Nanospheres Loaded with Sr with NLO Properties for Theranostic Applications in Radiotherapy. Preprints2024, 2024070688. https://doi.org/10.20944/preprints202407.0688.v1
Cioci, A.; Benzi, P.; Canepa, C.; Mortati, L.; Alvarez de la Paz, A.; Garnica-Palafox, I. M.; Sánchez‑Arévalo, F. M.; Dante, R. C.; Marabello, D. Fructose-Based Metal Organic Framework as a Means to Synthesize Chitosan Nanospheres Loaded with Sr with NLO Properties for Theranostic Applications in Radiotherapy. Preprints 2024, 2024070688. https://doi.org/10.20944/preprints202407.0688.v1
Cioci, A.; Benzi, P.; Canepa, C.; Mortati, L.; Alvarez de la Paz, A.; Garnica-Palafox, I. M.; Sánchez‑Arévalo, F. M.; Dante, R. C.; Marabello, D. Fructose-Based Metal Organic Framework as a Means to Synthesize Chitosan Nanospheres Loaded with Sr with NLO Properties for Theranostic Applications in Radiotherapy. Preprints2024, 2024070688. https://doi.org/10.20944/preprints202407.0688.v1
APA Style
Cioci, A., Benzi, P., Canepa, C., Mortati, L., Alvarez de la Paz, A., Garnica-Palafox, I. M., Sánchez‑Arévalo, F. M., Dante, R. C., & Marabello, D. (2024). Fructose-Based Metal Organic Framework as a Means to Synthesize Chitosan Nanospheres Loaded with Sr with NLO Properties for Theranostic Applications in Radiotherapy. Preprints. https://doi.org/10.20944/preprints202407.0688.v1
Chicago/Turabian Style
Cioci, A., Roberto C. Dante and Domenica Marabello. 2024 "Fructose-Based Metal Organic Framework as a Means to Synthesize Chitosan Nanospheres Loaded with Sr with NLO Properties for Theranostic Applications in Radiotherapy" Preprints. https://doi.org/10.20944/preprints202407.0688.v1
Abstract
Chitosan is a biodegradable polymer derived from chitin, that is a versatile material for various biological applications for its attractive properties such as biocompatibility, biodegradability, and non-toxicity. Furthermore, chitosan possesses Second Harmonic Generation properties, that are useful for bio-sensing applications.
In this work we explored the possibility to exploit chitosan-based nanospheres as SHG-based bio-sensors, and also as carriers of 89Sr radionuclide, an Active Pharmaceutical Ingredient for radiopharmaceutical treatments in cancer therapy. To load opportunely the Sr ion on the nanospheres, we used a fructose-based Metal Organic Framework, of formula [Sr(C6H12O6)2(H2O)2]Cl2·H2O, because the sugar was able to drive the Sr ions on the chitosan matrix.
The Sr-loaded chitosan nanospheres were synthetized, characterized, and their SHG response was measured. The results encouraged us to propose the nanospheres for theranostic purposes, i.e. at the same time valuable for both therapy and diagnostic applications.
Keywords
Metal Organic Frameworks; Chitosan nanospheres; theranostics; radiopharmaceutical; Second Harmonic Generation properties
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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