Version 1
: Received: 8 July 2024 / Approved: 9 July 2024 / Online: 9 July 2024 (07:00:20 CEST)
How to cite:
Singh, M.; Debas, A.; Joshi, G.; Okajima, M. K.; Rajan, R.; Matsumura, K.; Kaneko, T. Enhancing Gelatine Hydrogel Robustness with Sacran-aldehyde: A Natural Crosslinker Approach. Preprints2024, 2024070711. https://doi.org/10.20944/preprints202407.0711.v1
Singh, M.; Debas, A.; Joshi, G.; Okajima, M. K.; Rajan, R.; Matsumura, K.; Kaneko, T. Enhancing Gelatine Hydrogel Robustness with Sacran-aldehyde: A Natural Crosslinker Approach. Preprints 2024, 2024070711. https://doi.org/10.20944/preprints202407.0711.v1
Singh, M.; Debas, A.; Joshi, G.; Okajima, M. K.; Rajan, R.; Matsumura, K.; Kaneko, T. Enhancing Gelatine Hydrogel Robustness with Sacran-aldehyde: A Natural Crosslinker Approach. Preprints2024, 2024070711. https://doi.org/10.20944/preprints202407.0711.v1
APA Style
Singh, M., Debas, A., Joshi, G., Okajima, M. K., Rajan, R., Matsumura, K., & Kaneko, T. (2024). Enhancing Gelatine Hydrogel Robustness with Sacran-aldehyde: A Natural Crosslinker Approach. Preprints. https://doi.org/10.20944/preprints202407.0711.v1
Chicago/Turabian Style
Singh, M., Kazuaki Matsumura and Tatsuo Kaneko. 2024 "Enhancing Gelatine Hydrogel Robustness with Sacran-aldehyde: A Natural Crosslinker Approach" Preprints. https://doi.org/10.20944/preprints202407.0711.v1
Abstract
Tunable hydrogels have gained significant attention in the bioengineering field due to their designer preparation approach. Towards this end, gelatine stands out as a promising candidate owing to the desirable attributes, such as biocompatibility, ability to support cell adhesion and proliferation, biodegradability, along with being cost-effective. This study presents the preparation of a robust gelatine hydrogel employing sacran dialdehyde (SDA) as a natural crosslinker. The resulting SDA-crosslinked gelatine hydrogels (GSDA) display an optimal compressive stress of 0.15 MPa at 50% strain, five times higher as compared to pure gelatine hydrogel. As SDA crosslinking concentration is increased, swelling capacity of GSDA declines. Probing further with FTIR spectroscopy and SEM at the micron-scale unveiled a dual-crosslinking mechanism within the hydrogels. This mechanism encompasses both short- and long-range covalent crosslinking, along with thermo-reversible physical crosslinking, resulting in a significant enhancement of the load-bearing capacity of the fabricated hydrogels.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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