Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Managing Newborn Screening Recollections For Sick And Preterm Neonates

Version 1 : Received: 5 July 2024 / Approved: 9 July 2024 / Online: 9 July 2024 (13:09:12 CEST)

How to cite: Greaves, R.; Northfield, J.-A.; Cross, L.; Mawad, N.; Nguyen, T.; Tan, M.; O'Connell, M.; Pitt, J. Managing Newborn Screening Recollections For Sick And Preterm Neonates. Preprints 2024, 2024070770. https://doi.org/10.20944/preprints202407.0770.v1 Greaves, R.; Northfield, J.-A.; Cross, L.; Mawad, N.; Nguyen, T.; Tan, M.; O'Connell, M.; Pitt, J. Managing Newborn Screening Recollections For Sick And Preterm Neonates. Preprints 2024, 2024070770. https://doi.org/10.20944/preprints202407.0770.v1

Abstract

Some preterm and sick neonates have altered biochemical profiles and follow-up newborn screening (NBS) collections are recommended. The Victorian NBS program historically recommended recollections for babies with birth weight <1500g (managed by the maternity service provider) and 3 weeks post-transfusion (managed by the laboratory). We aimed to determine adherence to current guidelines and review the guidelines to improve NBS performance. To do this we audited data from 348,584 babies between January 2018 and June 2022. Babies with a recorded birth weight of <1500g were filtered for inclusion. For the overall review and visualization of the protocol, we sourced information from the literature, our professional society and tertiary hospital services. A total of 2647 babies had a birth weight recorded between 200 and 1499g. Of these 2036 (77%) had a second sample collected, indicating that >1 in 5 babies were not receiving a follow-up collection. Our timing of recollections for transfused babies, requiring a 3-week follow-up collection, was longer than in other Australasian jurisdictions. A new combined “sick-prem-protocol” was launched to support recollections and after a one-year review achieve 95% compliance. We recommend NBS laboratories audit preterm and sick neonate recollections to ensure appropriate follow-up. This should be supported with a visual process map to aid education and compliance.

Keywords

Prematurity; low birth weight; transfusion; sick neonate; quality indicators; congenital hypothyroidism; transient hypothyroidism, congenital adrenal hyperplasia

Subject

Public Health and Healthcare, Public Health and Health Services

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