Calvo Sánchez, N.; Sancha Domínguez, L.; Cotos Suárez, A.; Muñoz Bellido, J. L. Aeromonas Infections in Humans. Antibiotic Resistance and Treatment Options. Preprints2024, 2024070809. https://doi.org/10.20944/preprints202407.0809.v1
APA Style
Calvo Sánchez, N., Sancha Domínguez, L., Cotos Suárez, A., & Muñoz Bellido, J. L. (2024). Aeromonas Infections in Humans. Antibiotic Resistance and Treatment Options. Preprints. https://doi.org/10.20944/preprints202407.0809.v1
Chicago/Turabian Style
Calvo Sánchez, N., Ana Cotos Suárez and Juan Luis Muñoz Bellido. 2024 "Aeromonas Infections in Humans. Antibiotic Resistance and Treatment Options" Preprints. https://doi.org/10.20944/preprints202407.0809.v1
Abstract
The genus Aeromonas is widely distributed in aquatic environments. It is frequent as a fish pathogen, but has also been described associated to human infections. Most human cases are caused by A. caviae, A. veronii biovar sobria, and A. hydrophila, though A. dhakensis is becoming increasingly important. Transmission happens primarily by ingestion or contact with aquatic collections, or by consumption of contaminated food, especially of aquatic origin. Increasing resistance has been described in Aeromonas to penicillins, including their combinations with classical b-lactamase inhibitors, cephalosporins and carbapenems. Among the b-lactam antibiotics, only the 4th generation cephalosporins remain almost uniformly active. In addition, the simultaneous presence of resistance genes to 3rd generation cephalosporins and carbapenems in the same isolates is increasing. Recently, the presence of mobile genes linked to colistin resistance has also been described, in some cases with resistance percentages higher than 30%. Most likely, this evolution of colistin resistance is linked to its use in aquaculture, and, together with the evolution of b-lactam resistance, may be turning this genus into a reservoir of resistance genes that may affect other species much more frequently linked to human infections, such as Enterobacterales.
Keywords
Aeromonas; human infections; antibiotic resistance
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
