Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Monitoring Influence of Hand, Foot and Mouth Disease New Guidelines on Patients Care during the 2011–2012 Multiwaves and Multivariants Outbreak in Hai Phong City, Vietnam

Version 1 : Received: 9 July 2024 / Approved: 10 July 2024 / Online: 10 July 2024 (05:08:25 CEST)

How to cite: Duy, N. N.; Huong, L. T. T.; Ravel, P.; Huong, L. T. S.; Dwivedi, A.; Kister, G.; Gavotte, L.; Devaux, C. A.; Thien, V. D.; Thanh, N. T. H.; Duong, T. N.; Hien Nguyen, T.; Cornillot, E.; Frutos, R. Monitoring Influence of Hand, Foot and Mouth Disease New Guidelines on Patients Care during the 2011–2012 Multiwaves and Multivariants Outbreak in Hai Phong City, Vietnam. Preprints 2024, 2024070817. https://doi.org/10.20944/preprints202407.0817.v1 Duy, N. N.; Huong, L. T. T.; Ravel, P.; Huong, L. T. S.; Dwivedi, A.; Kister, G.; Gavotte, L.; Devaux, C. A.; Thien, V. D.; Thanh, N. T. H.; Duong, T. N.; Hien Nguyen, T.; Cornillot, E.; Frutos, R. Monitoring Influence of Hand, Foot and Mouth Disease New Guidelines on Patients Care during the 2011–2012 Multiwaves and Multivariants Outbreak in Hai Phong City, Vietnam. Preprints 2024, 2024070817. https://doi.org/10.20944/preprints202407.0817.v1

Abstract

In 2011-2012, Northern Vietnam suffered its first large scale hand foot and mouth disease (HFMD) epidemic. Two sets of official guidelines were issued during the outbreak to handle the HFMD crisis. The city of Hai Phong was therefore used as a model to analyze the impact of the guidelines release. 9621 HFMD cases were reported in Hai Phong city from April 2011 to December 2012. Three distinct waves of HFMD occurred. Enterovirus A71 and Coxackievirus A16 were successively associated to the epidemics. Two periods, before and after guidelines realease, could be distinguished which were characterized by different patient patterns Time to admission and severity changed notably. Guideline publication help the health system refocusing on the 0.5-3 years age group with highest incidence of the disease. The three waves showed different special distribution but main routes of infection were rivers and local secondary roads most likely through local trade and occupational movements of people.

Keywords

HFMD; Enterovirus; Coxakievirus; EV-A71; CV-A6; CV-A16; Hai Phong; Vietnam

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

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