Version 1
: Received: 10 July 2024 / Approved: 11 July 2024 / Online: 11 July 2024 (12:42:26 CEST)
How to cite:
Cervantes-Monroy, E.; Zarzoza-Mendoza, I. C.; Canizales-Quinteros, S.; Moran-Ramos, S.; Villa-Morales, J.; López-Contreras, B.; Carmona-Sierra, F. V.; Rodríguez-Cruz, A. M. Influence of Early Life Factors on the Breast Milk and Fecal Microbiota of Mother-Newborn Dyads. Preprints2024, 2024070910. https://doi.org/10.20944/preprints202407.0910.v1
Cervantes-Monroy, E.; Zarzoza-Mendoza, I. C.; Canizales-Quinteros, S.; Moran-Ramos, S.; Villa-Morales, J.; López-Contreras, B.; Carmona-Sierra, F. V.; Rodríguez-Cruz, A. M. Influence of Early Life Factors on the Breast Milk and Fecal Microbiota of Mother-Newborn Dyads. Preprints 2024, 2024070910. https://doi.org/10.20944/preprints202407.0910.v1
Cervantes-Monroy, E.; Zarzoza-Mendoza, I. C.; Canizales-Quinteros, S.; Moran-Ramos, S.; Villa-Morales, J.; López-Contreras, B.; Carmona-Sierra, F. V.; Rodríguez-Cruz, A. M. Influence of Early Life Factors on the Breast Milk and Fecal Microbiota of Mother-Newborn Dyads. Preprints2024, 2024070910. https://doi.org/10.20944/preprints202407.0910.v1
APA Style
Cervantes-Monroy, E., Zarzoza-Mendoza, I. C., Canizales-Quinteros, S., Moran-Ramos, S., Villa-Morales, J., López-Contreras, B., Carmona-Sierra, F. V., & Rodríguez-Cruz, A. M. (2024). Influence of Early Life Factors on the Breast Milk and Fecal Microbiota of Mother-Newborn Dyads. Preprints. https://doi.org/10.20944/preprints202407.0910.v1
Chicago/Turabian Style
Cervantes-Monroy, E., Fairt V. Carmona-Sierra and and Maricela Rodríguez-Cruz. 2024 "Influence of Early Life Factors on the Breast Milk and Fecal Microbiota of Mother-Newborn Dyads" Preprints. https://doi.org/10.20944/preprints202407.0910.v1
Abstract
Maternal gut and breast milk (BM) are key in vertically transmission bacteria to infants, shaping their gut microbiota in early life. Although the establishment of early gut microbiota is known, the role of the combined influence of maternal factors and newborn characteristics are not explored. In this study we aimed to assess the influence of maternal BMI and total body fat, age, delivery mode, and newborn sex on the diversity and composition of the BM and gut microbiota (GM) in mother- newborn dyads. In this cross-sectional study, of the 986 pregnant women candidates, 53 participated, and finally, 40 mother-newborn dyads exclusively breastfeeding at 20-28 days post-partum were included. Metataxonomic profiling of DNA extracted from BM and fecal samples was conducted using 16S rRNA sequencing. Globally, the findings offer valuable insights that excessive adiposity, age and C-section delivery influence on a lower abundance of specific taxa in the BM, maternal gut, and gut newborns. Also, the simultaneous analysis of maternal factors and newborn characteristics shows that maternal age and newborn sex explain an important variation in the microbiota composition. These results add to understanding of the intricate interplay between maternal factors and the microbial communities that influence early-life gut and BM microbiota.
Keywords
mom-newborn dyad; gut microbiota; breast milk, newborn sex, age, nutrition status, delivery mode, early-life microbiota
Subject
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
