Version 1
: Received: 10 July 2024 / Approved: 11 July 2024 / Online: 11 July 2024 (04:52:29 CEST)
How to cite:
Pezzuoli, C.; Biagini, G.; Magistroni, R. Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review of Current Evidence. Preprints2024, 2024070919. https://doi.org/10.20944/preprints202407.0919.v1
Pezzuoli, C.; Biagini, G.; Magistroni, R. Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review of Current Evidence. Preprints 2024, 2024070919. https://doi.org/10.20944/preprints202407.0919.v1
Pezzuoli, C.; Biagini, G.; Magistroni, R. Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review of Current Evidence. Preprints2024, 2024070919. https://doi.org/10.20944/preprints202407.0919.v1
APA Style
Pezzuoli, C., Biagini, G., & Magistroni, R. (2024). Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review of Current Evidence. Preprints. https://doi.org/10.20944/preprints202407.0919.v1
Chicago/Turabian Style
Pezzuoli, C., Giuseppe Biagini and Riccardo Magistroni. 2024 "Ketogenic Interventions in Autosomal Dominant Polycystic Kidney Disease: A Comprehensive Review of Current Evidence" Preprints. https://doi.org/10.20944/preprints202407.0919.v1
Abstract
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder characterized by the development and progression of multiple renal cysts, leading to progressive renal function decline. To date, the only approved treatment for this condition is able to slow down the loss of annual renal function, without stopping the disease progression. Furthermore, this therapy is approved only for patients with rapid disease progression and its compliance is problematic because of the impact of this drug on quality of life. The recent literature suggests that cystic cells are subject to metabolic dysregulation in the glucose pathway (Warburg Effect). This finding paved the way for new lines of research targeting potential therapeutic interventions for ADPKD. In particular, this review highlights the latest studies on the use of ketosis, through ketogenic dietary interventions (daily calorie restriction, intermittent fasting, time-restricted feeding, and ketogenic diets), as a potential strategy for patients with ADPKD, and the possible involvement of microbiota in the ketogenic interventions’ effect.
Keywords
ADPKD; ketogenic diet; ketosis; kidney cysts; PKD; renal function decline
Subject
Medicine and Pharmacology, Urology and Nephrology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
