Preprint Communication Version 1 This version is not peer-reviewed

Synthesis of tetrahydroberberine N,N-derived O-acetamides

Version 1 : Received: 12 July 2024 / Approved: 12 July 2024 / Online: 13 July 2024 (00:04:01 CEST)

How to cite: Nechepurenko, I. V.; Komarova, N. I.; Salakhutdinov, N. F. Synthesis of tetrahydroberberine N,N-derived O-acetamides. Preprints 2024, 2024071047. https://doi.org/10.20944/preprints202407.1047.v1 Nechepurenko, I. V.; Komarova, N. I.; Salakhutdinov, N. F. Synthesis of tetrahydroberberine N,N-derived O-acetamides. Preprints 2024, 2024071047. https://doi.org/10.20944/preprints202407.1047.v1

Abstract

The reaction of berberine derivatives containing at O-9 position N,N-disubstituted acetamide fragments with sodium borohydride in methanol at 0 °C leads to a mild reduction of the "C" cycle with the formation of corresponding tetrahydroberberine derivatives with moderate to good yields.

Keywords

berberine; berberubine; tetrahydroberberine; tetrahydroberberrubine; acetamides.

Subject

Chemistry and Materials Science, Organic Chemistry

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