Version 1
: Received: 11 July 2024 / Approved: 12 July 2024 / Online: 15 July 2024 (19:33:43 CEST)
How to cite:
Moreira, J. V. M. E.; Bernardi, L. P.; Teixeira, F. C.; Paniago, J.; Teixeira, L. V.; Bifi, F.; de Souza, D. O.; Rohden, F. Spontaneously Hypertensive Rats Present Exacerbated Focal Stroke Behavioral Outcomes. Preprints2024, 2024071068. https://doi.org/10.20944/preprints202407.1068.v1
Moreira, J. V. M. E.; Bernardi, L. P.; Teixeira, F. C.; Paniago, J.; Teixeira, L. V.; Bifi, F.; de Souza, D. O.; Rohden, F. Spontaneously Hypertensive Rats Present Exacerbated Focal Stroke Behavioral Outcomes. Preprints 2024, 2024071068. https://doi.org/10.20944/preprints202407.1068.v1
Moreira, J. V. M. E.; Bernardi, L. P.; Teixeira, F. C.; Paniago, J.; Teixeira, L. V.; Bifi, F.; de Souza, D. O.; Rohden, F. Spontaneously Hypertensive Rats Present Exacerbated Focal Stroke Behavioral Outcomes. Preprints2024, 2024071068. https://doi.org/10.20944/preprints202407.1068.v1
APA Style
Moreira, J. V. M. E., Bernardi, L. P., Teixeira, F. C., Paniago, J., Teixeira, L. V., Bifi, F., de Souza, D. O., & Rohden, F. (2024). Spontaneously Hypertensive Rats Present Exacerbated Focal Stroke Behavioral Outcomes. Preprints. https://doi.org/10.20944/preprints202407.1068.v1
Chicago/Turabian Style
Moreira, J. V. M. E., Diogo Onofre de Souza and Francieli Rohden. 2024 "Spontaneously Hypertensive Rats Present Exacerbated Focal Stroke Behavioral Outcomes" Preprints. https://doi.org/10.20944/preprints202407.1068.v1
Abstract
This study aimed to compare the effects of a permanent ischemic stroke model (focal ischemia by thermocoagulation of pial vessels) on sensorimotor function (cylinder test and adhesive removal test), behavioral tasks (novelty habituation memory-open field task), and cerebral infarct size in adult male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats over 42 days after the occurrence of stroke. We observed that the stroke caused asymmetry in the front paws and delayed adhesive removal. These effects were spontaneously reduced in WKY rats, but not in SHR. Short- and long-term novelty habituation memories were abolished by stroke in WYK and SHR. On the 3rd day after stroke, the size of the focal cerebral infarct was the same in WKY and SHR. However, on the 7th day, the infarct size decreased in WKY rats, but not SHR. These results suggested that SAH impairment of sensorimotor recovery in rats subjected to cerebral ischemia could be related to augmented focal cerebral infarct size. Moreover, the behavioral tasks used in this study were unaffected by Systemic Arterial Hypertension. Our results highlight the need for animal models of comorbidities in stroke research.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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