Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Yandra Cervelim Nunes; Nathalia. M. Mendes; Enzo Pereira de Lima; Amanda Chabrour Chehadi; Caroline Barbalho Lamas; Jesselina F. S. Haber; Manoela dos Santos Bueno; Adriano Cressoni Araújo; Vitor C. Strozze Catharin; Claudia Rucco. P. Detregiachi; Lucas Fornari Laurindo; Masaru Tanaka; Sandra Maria Barbalho; Maria José Sanches Marin

doi:10.20944/preprints202407.1076.v1

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preprints.org > medicine and pharmacology > dietetics and nutrition > doi: 10.20944/preprints202407.1076.v1 (registering DOI)

Preprint Review Version 1 This version is not peer-reviewed

Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Yandra Cervelim Nunes

Nathalia. M. Mendes

Enzo Pereira de Lima

Amanda Chabrour Chehadi

Caroline Barbalho Lamas

Jesselina F. S. Haber

Manoela dos Santos Bueno

Adriano Cressoni Araújo

Vitor C. Strozze Catharin

Claudia Rucco. P. Detregiachi

Lucas Fornari Laurindo

Masaru Tanaka

^* ,

Sandra Maria Barbalho

^* ,

Maria José Sanches Marin

Version 1 : Received: 12 July 2024 / Approved: 12 July 2024 / Online: 12 July 2024 (14:59:33 CEST)

How to cite: Nunes, Y. C.; Mendes, N. M.; Pereira de Lima, E.; Chehadi, A. C.; Lamas, C. B.; Haber, J. F. S.; dos Santos Bueno, M.; Araújo, A. C.; Catharin, V. C. S.; Detregiachi, C. R. P.; Laurindo, L. F.; Tanaka, M.; Barbalho, S. M.; Marin, M. J. S. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence. Preprints 2024, 2024071076. https://doi.org/10.20944/preprints202407.1076.v1 Nunes, Y. C.; Mendes, N. M.; Pereira de Lima, E.; Chehadi, A. C.; Lamas, C. B.; Haber, J. F. S.; dos Santos Bueno, M.; Araújo, A. C.; Catharin, V. C. S.; Detregiachi, C. R. P.; Laurindo, L. F.; Tanaka, M.; Barbalho, S. M.; Marin, M. J. S. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence. Preprints 2024, 2024071076. https://doi.org/10.20944/preprints202407.1076.v1

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MDPI and ACS Style

Nunes, Y. C.; Mendes, N. M.; Pereira de Lima, E.; Chehadi, A. C.; Lamas, C. B.; Haber, J. F. S.; dos Santos Bueno, M.; Araújo, A. C.; Catharin, V. C. S.; Detregiachi, C. R. P.; Laurindo, L. F.; Tanaka, M.; Barbalho, S. M.; Marin, M. J. S. Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence. Preprints 2024, 2024071076. https://doi.org/10.20944/preprints202407.1076.v1

APA Style

Nunes, Y. C., Mendes, N. M., Pereira de Lima, E., Chehadi, A. C., Lamas, C. B., Haber, J. F. S., dos Santos Bueno, M., Araújo, A. C., Catharin, V. C. S., Detregiachi, C. R. P., Laurindo, L. F., Tanaka, M., Barbalho, S. M., & Marin, M. J. S. (2024). Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence. Preprints. https://doi.org/10.20944/preprints202407.1076.v1

Chicago/Turabian Style

Nunes, Y. C., Sandra Maria Barbalho and Maria José Sanches Marin. 2024 "Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence" Preprints. https://doi.org/10.20944/preprints202407.1076.v1

Abstract

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, and mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant and anti-inflammatory properties, has emerged as a promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms of curcumin's effects and the optimal dosages for different conditions necessitate further investigation. This systematic review synthesizes current evidence on curcumin's potential in addressing age-related disorders, emphasizing its impact on cognitive function, neurodegeneration, and muscle health in older adults. By evaluating the safety, efficacy, and mechanisms of action of curcumin supplementation, this review aims to provide insights into its therapeutic potential for promoting healthy aging. A systematic search across three databases using specific keywords yielded 2,256 documents, leading to the selection of 15 clinical trials for synthesis. Here we highlight the promising potential of curcumin as a multifaceted therapeutic agent in combating age-related disorders. The findings of this review suggest that curcumin could offer a natural and effective approach to enhancing the quality of life of aging individuals. Further research and well-designed clinical trials are essential to validate these findings and optimize the use of curcumin in personalized medicine approaches for age-related conditions.

Keywords

Curcuma longa; curcumin; aging; inflammation; oxidative stress; frailty; neurodegeneration; sarcopenia; cardiovascular diseases; clinical trials

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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