PreprintArticleVersion 1This version is not peer-reviewed
Moderate Overweight of Male Rats Chronically Fed with a Hyperlipidic Diet Developed Early Silent Ang-(3–4)-Sensitive Myocardial Molecular Lesions and Preserved Echographic Parameters
Version 1
: Received: 12 July 2024 / Approved: 13 July 2024 / Online: 15 July 2024 (10:33:35 CEST)
How to cite:
Crisóstomo, T.; Luzes, R.; Gonçalves, M. L. L.; Pardal, M. A. E.; Muzi-Filho, H.; Costa-Sarmento, G.; Mello, D. B.; Vieyra, A. Moderate Overweight of Male Rats Chronically Fed with a Hyperlipidic Diet Developed Early Silent Ang-(3–4)-Sensitive Myocardial Molecular Lesions and Preserved Echographic Parameters. Preprints2024, 2024071120. https://doi.org/10.20944/preprints202407.1120.v1
Crisóstomo, T.; Luzes, R.; Gonçalves, M. L. L.; Pardal, M. A. E.; Muzi-Filho, H.; Costa-Sarmento, G.; Mello, D. B.; Vieyra, A. Moderate Overweight of Male Rats Chronically Fed with a Hyperlipidic Diet Developed Early Silent Ang-(3–4)-Sensitive Myocardial Molecular Lesions and Preserved Echographic Parameters. Preprints 2024, 2024071120. https://doi.org/10.20944/preprints202407.1120.v1
Crisóstomo, T.; Luzes, R.; Gonçalves, M. L. L.; Pardal, M. A. E.; Muzi-Filho, H.; Costa-Sarmento, G.; Mello, D. B.; Vieyra, A. Moderate Overweight of Male Rats Chronically Fed with a Hyperlipidic Diet Developed Early Silent Ang-(3–4)-Sensitive Myocardial Molecular Lesions and Preserved Echographic Parameters. Preprints2024, 2024071120. https://doi.org/10.20944/preprints202407.1120.v1
APA Style
Crisóstomo, T., Luzes, R., Gonçalves, M. L. L., Pardal, M. A. E., Muzi-Filho, H., Costa-Sarmento, G., Mello, D. B., & Vieyra, A. (2024). Moderate Overweight of Male Rats Chronically Fed with a Hyperlipidic Diet Developed Early Silent Ang-(3–4)-Sensitive Myocardial Molecular Lesions and Preserved Echographic Parameters. Preprints. https://doi.org/10.20944/preprints202407.1120.v1
Chicago/Turabian Style
Crisóstomo, T., Debora B. Mello and Adalberto Vieyra. 2024 "Moderate Overweight of Male Rats Chronically Fed with a Hyperlipidic Diet Developed Early Silent Ang-(3–4)-Sensitive Myocardial Molecular Lesions and Preserved Echographic Parameters" Preprints. https://doi.org/10.20944/preprints202407.1120.v1
Abstract
Overweight/obesity and cardiovascular diseases are associated with high rates of mobility and mortality. We investigated inflammatory lesions and ionic transporters in the left ventricle of male rats chronically fed a high-fat diet (HL). They developed moderate overweight with early expansion of visceral adiposity. The inflammatory markers interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-), Na+-transporting ATPases, sarco-endoplasmic reticulum Ca2+-ATPase (SERCA2a), and the abundance of Angiotensin II receptors were studied together with lipid and glycemic profiles, and the left ventricle echocardiographic parameters fractional shortening (FS) and ejection fraction (EF). HL rats doubled IL-6 and TNF-, which returned to normal levels when signaling coupled to Angiotensin II type 2 receptors (AT2R) was supraregulated by Ang-(3–4) administration. The decreased glucose tolerance was accompanied by significantly reduced plasma triglycerides due to intense hepatic steatosis (Crisóstomo et al. Metabolism Open. 2022, 14, 100176). AT2R (and AT1R) abundance did not change. (Na++K+)ATPase and ouabain-resistant Na+-ATPase were downregulated and upregulated, respectively, normalized with Ang-(3–4). SERCA2a lost its most critical regulatory property, inhibition by excess substrate. The ultrasound showed no changes in FS and EF. We conclude that very moderate overweight can cause silent initial molecular tissue damage in heart, which can evolve to cause systolic dysfunction.
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
