PreprintArticleVersion 1This version is not peer-reviewed
Fabrication of a Microfluidic-Based Device Coated with Polyelec-Trolyte-Capped-Titanium Dioxide to Couple High-Performance Liquid Chromatography with Inductively Coupled Plasma-Mass Spectrometry for Mercury Speciation
Chen, J.-H.; Luo, Y.-T.; Su, Y.-A.; Ke, Y.-R.; Deng, M.-J.; Chen, W.-Y.; Wang, C.-Y.; Tsai, J.-L.; Lin, C.-H.; Shih, T.-T. Fabrication of a Microfluidic-Based Device Coated with Polyelec-Trolyte-Capped-Titanium Dioxide to Couple High-Performance Liquid Chromatography with Inductively Coupled Plasma-Mass Spectrometry for Mercury Speciation. Preprints2024, 2024071178. https://doi.org/10.20944/preprints202407.1178.v1
APA Style
Chen, J. H., Luo, Y. T., Su, Y. A., Ke, Y. R., Deng, M. J., Chen, W. Y., Wang, C. Y., Tsai, J. L., Lin, C. H., & Shih, T. T. (2024). Fabrication of a Microfluidic-Based Device Coated with Polyelec-Trolyte-Capped-Titanium Dioxide to Couple High-Performance Liquid Chromatography with Inductively Coupled Plasma-Mass Spectrometry for Mercury Speciation. Preprints. https://doi.org/10.20944/preprints202407.1178.v1
Chicago/Turabian Style
Chen, J., Cheng-Hsing Lin and Tsung-Ting Shih. 2024 "Fabrication of a Microfluidic-Based Device Coated with Polyelec-Trolyte-Capped-Titanium Dioxide to Couple High-Performance Liquid Chromatography with Inductively Coupled Plasma-Mass Spectrometry for Mercury Speciation" Preprints. https://doi.org/10.20944/preprints202407.1178.v1
Abstract
Mercury (Hg) is a toxic element impacting on biological systems and ecosystems. Because the toxicity of Hg species is highly dependent on concentration levels and chemical forms, sensitive identification of chemical forms for Hg, i.e., Hg speciation, is of major significance in providing meaningful information about the source of Hg exposure. In this study, a microfluidic-based device made of high clarity poly(methyl methacrylate) (PMMA) was fabricated. Then titanium dioxide nanoparticles (nano-TiO2) were attached to the treated channel interior with the aid of poly(diallyldimethylammonium chloride) (PDADMAC). After coupling the nano-TiO2-coated microfluidic-based photocatalyst-assisted reduction device (the nano-TiO2-coated microfluid-ic-based PCARD) with high-performance liquid chromatography (HPLC) and inductively coupled plasma-mass spectrometry (ICP-MS), a selective and sensitive hyphenated system for Hg specia-tion was established. Validation procedures demonstrated that the method could be satisfactorily applied to the determination of mercuric ion (Hg2+) and methylmercury ion (CH3Hg+) in both human urine and water samples. Remarkably, the zeta potential measured clearly indicated the PDADMAC-capped nano-TiO2 with predominance of positive charges indeed provided steady force for firm attachment to the negatively charged device channel. The cause for the durability of the nano-TiO2-coated microfluidic-based PCARD was clarified thus.
Chemistry and Materials Science, Analytical Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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