The FLARE Score and Circulating Neutrophils in Patients with Cancer and COVID-19 Disease.

Elia Seguí; Juan Torres Canizales; Edouard Auclin; David Casadevall; Sara Peiro Carmona; Juan Aguilar-Company; Marta García de Herreros; Juan Carlos Laguna; Teresa Gorria; Marta Rodríguez; Azucena Gonzalez; Nicolas Epaillard; Javier Gavira; Victor Bolaño; Jose Carlos Tapia; Marco Tagliamento; Cristina Teixidó; Hugo Arasanz; Sara Pilotto; Rafael López Castro; Xabier Mielgo; Cristina Urbano; Gonzalo Recondo; Mar Diaz Pavon; Virginia Bluthgen; José Nicolas Minatta; Lorena Lupinacci; Fara Brasó-Maristany; Aleix Prat; Alexandru Vlagea; Laura Mezquita

doi:10.20944/preprints202407.1205.v1

How to cite: Seguí, E.; Torres Canizales, J.; Auclin, E.; Casadevall, D.; Peiro Carmona, S.; Aguilar-Company, J.; García de Herreros, M.; Laguna, J. C.; Gorria, T.; Rodríguez, M.; Gonzalez, A.; Epaillard, N.; Gavira, J.; Bolaño, V.; Tapia, J. C.; Tagliamento, M.; Teixidó, C.; Arasanz, H.; Pilotto, S.; López Castro, R.; Mielgo, X.; Urbano, C.; Recondo, G.; Diaz Pavon, M.; Bluthgen, V.; Minatta, J. N.; Lupinacci, L.; Brasó-Maristany, F.; Prat, A.; Vlagea, A.; Mezquita, L. The FLARE Score and Circulating Neutrophils in Patients with Cancer and COVID-19 Disease.. Preprints 2024, 2024071205. https://doi.org/10.20944/preprints202407.1205.v1 Seguí, E.; Torres Canizales, J.; Auclin, E.; Casadevall, D.; Peiro Carmona, S.; Aguilar-Company, J.; García de Herreros, M.; Laguna, J. C.; Gorria, T.; Rodríguez, M.; Gonzalez, A.; Epaillard, N.; Gavira, J.; Bolaño, V.; Tapia, J. C.; Tagliamento, M.; Teixidó, C.; Arasanz, H.; Pilotto, S.; López Castro, R.; Mielgo, X.; Urbano, C.; Recondo, G.; Diaz Pavon, M.; Bluthgen, V.; Minatta, J. N.; Lupinacci, L.; Brasó-Maristany, F.; Prat, A.; Vlagea, A.; Mezquita, L. The FLARE Score and Circulating Neutrophils in Patients with Cancer and COVID-19 Disease.. Preprints 2024, 2024071205. https://doi.org/10.20944/preprints202407.1205.v1

Abstract

Purpose: Inflammation and neutrophils play a central role in both Covid-19 disease and cancer. We aimed to assess the impact of pre-existing tumor-related inflammation on Covid-19 outcomes in patients with cancer and to elucidate the role of circulating neutrophil subpopulations. Methods: We conducted a multicenter retrospective analysis of 524 patients with cancer and SARS-CoV-2 infection, assessing the relationship between clinical outcomes and circulating inflammatory biomarkers collected before and during Covid-19 infection. Additionally, a unicenter prospective cohort provided data for an exploratory analysis, assessing the immunophenotype of circulating neutrophils and inflammatory cytokines. The primary endpoints were 30-day mortality and severity of Covid-19 disease. Results: Prior to Covid-19, 25% of patients with cancer exhibited elevated dNLR, which increase to 55% at the time of Covid-19 diagnosis. We developed the FLARE score, incorporating both tumor and infection-induced inflammation, which categorized patients into four prognostic groups. The poor prognostic group had a 30-day mortality rate of 68%, significantly higher than the 23% in the favorable group (p

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The FLARE Score and Circulating Neutrophils in Patients with Cancer and COVID-19 Disease.

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