The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria-Tetanus-Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring Roles of Heterologous Immunity

Theresia Santi; Juandy Jo; Alida Roswita Harahap; Retno Asti Werdhani; Sri Rezeki S. Hadinegoro; Ivo Novita SahBandar; Ari Prayitno; Zakiudin Munasir; Yvan Vandenplas; Badriul Hegar

doi:10.20944/preprints202407.1236.v1

How to cite: Santi, T.; Jo, J.; Harahap, A. R.; Werdhani, R. A.; Hadinegoro, S. R. S.; SahBandar, I. N.; Prayitno, A.; Munasir, Z.; Vandenplas, Y.; Hegar, B. The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria-Tetanus-Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring Roles of Heterologous Immunity. Preprints 2024, 2024071236. https://doi.org/10.20944/preprints202407.1236.v1 Santi, T.; Jo, J.; Harahap, A. R.; Werdhani, R. A.; Hadinegoro, S. R. S.; SahBandar, I. N.; Prayitno, A.; Munasir, Z.; Vandenplas, Y.; Hegar, B. The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria-Tetanus-Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring Roles of Heterologous Immunity. Preprints 2024, 2024071236. https://doi.org/10.20944/preprints202407.1236.v1

Abstract

Background: Routine childhood vaccination, e.g., for diphtheria-tetanus-pertussis (DTP), might provide an additional protection towards SARS-CoV-2 infection. This concept of heterologous immunity was explored in healthy children receiving both DTP and inactivated SARS-CoV-2 vaccines. Methods: A cross-sectional study was performed on 154 healthy children aged 6–8 years old in Jakarta, Indonesia. Their vaccination status of DTP (including diphtheria-tetanus booster vac-cine at 5 years old) and CoronaVac (from 6 years old) were recorded. Peripheral blood samples were collected from all participants, in which anti-diphtheria toxoid IgG, anti-SARS-CoV-2 S-RBD antibodies and T cell-derived IFN- were measured. Results: Study participants with complete DTP vaccination had significantly higher titer of an-ti-diphtheria toxoid IgG than the ones without (median=0.9349 versus 0.2113 IU/mL; p

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria-Tetanus-Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring Roles of Heterologous Immunity

Abstract

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