Version 1
: Received: 17 July 2024 / Approved: 17 July 2024 / Online: 17 July 2024 (11:39:53 CEST)
How to cite:
Naz, M.; Zhang, D.; Liao, K.; Chen, X.; Ahmed, N.; Zhou, J.-J.; Chen, Z. The Past, Present and Future of Plant Activator Targeting Salicylic Acid Signal Pathway. Preprints2024, 2024071424. https://doi.org/10.20944/preprints202407.1424.v1
Naz, M.; Zhang, D.; Liao, K.; Chen, X.; Ahmed, N.; Zhou, J.-J.; Chen, Z. The Past, Present and Future of Plant Activator Targeting Salicylic Acid Signal Pathway. Preprints 2024, 2024071424. https://doi.org/10.20944/preprints202407.1424.v1
Naz, M.; Zhang, D.; Liao, K.; Chen, X.; Ahmed, N.; Zhou, J.-J.; Chen, Z. The Past, Present and Future of Plant Activator Targeting Salicylic Acid Signal Pathway. Preprints2024, 2024071424. https://doi.org/10.20944/preprints202407.1424.v1
APA Style
Naz, M., Zhang, D., Liao, K., Chen, X., Ahmed, N., Zhou, J. J., & Chen, Z. (2024). The Past, Present and Future of Plant Activator Targeting Salicylic Acid Signal Pathway. Preprints. https://doi.org/10.20944/preprints202407.1424.v1
Chicago/Turabian Style
Naz, M., Jing-Jiang Zhou and Zhuo Chen. 2024 "The Past, Present and Future of Plant Activator Targeting Salicylic Acid Signal Pathway" Preprints. https://doi.org/10.20944/preprints202407.1424.v1
Abstract
Plant activators have emerged as promising alternatives to conventional pesticides for crop disease manage-ment due to their unique mode of action. By priming the plant's innate immune system, these compounds can induce systemic acquired resistance against a broad spectrum of pathogens without directly inhibiting their proliferation. Key advantages of plant activators include prolonged defense activity, lower effective dosages, and negligible risk of developing pathogen resistance. Among the various defensive pathways tar-geted, the salicylic acid (SA) signaling cascade has been extensively explored, leading to the successful devel-opment of commercial activators like benzothiadiazole for widespread application in crop protection. While the action sites of many SA-targeting activators have been preliminarily mapped to different steps along the pathway, a comprehensive understanding of their precise mechanisms remains elusive. This review provides a historical perspective on plant activator development and outlines diverse screening strategies employed across multiple levels, from whole-plant bioassays to molecular and transgenic approaches. We expound on the intricate components, biological relevance, and regulatory circuits governing the SA pathway, while criti-cally examining the structural features, bioactivities, and proposed modes of action of classical activators such as benzothiadiazole derivatives, salicylic acid analogs, and other small molecules. Insights from field trials as-sessing their practical applicability are also discussed. Furthermore, we highlight the current status, challenges, and future prospects in the realm of SA-targeting activator development globally, with a focus on recent en-deavors in China. Collectively, this comprehensive review aims to synthesize existing knowledge and provide a roadmap for future research toward developing more potent and mechanistically understood plant activa-tors that fortify crop immunity against disease.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
