Version 1
: Received: 17 July 2024 / Approved: 18 July 2024 / Online: 18 July 2024 (11:28:31 CEST)
How to cite:
PLEBANI, M.; Zaninotto, M.; Giannini, S.; Sella, S.; Fusaro, M.; Tripepi, G. L.; Gallieni, M.; Herrmann, M.; Cozzolino, M. Vitamin D Assay and Supplementation: Still Debatable Issues. Preprints2024, 2024071461. https://doi.org/10.20944/preprints202407.1461.v1
PLEBANI, M.; Zaninotto, M.; Giannini, S.; Sella, S.; Fusaro, M.; Tripepi, G. L.; Gallieni, M.; Herrmann, M.; Cozzolino, M. Vitamin D Assay and Supplementation: Still Debatable Issues. Preprints 2024, 2024071461. https://doi.org/10.20944/preprints202407.1461.v1
PLEBANI, M.; Zaninotto, M.; Giannini, S.; Sella, S.; Fusaro, M.; Tripepi, G. L.; Gallieni, M.; Herrmann, M.; Cozzolino, M. Vitamin D Assay and Supplementation: Still Debatable Issues. Preprints2024, 2024071461. https://doi.org/10.20944/preprints202407.1461.v1
APA Style
PLEBANI, M., Zaninotto, M., Giannini, S., Sella, S., Fusaro, M., Tripepi, G. L., Gallieni, M., Herrmann, M., & Cozzolino, M. (2024). Vitamin D Assay and Supplementation: Still Debatable Issues. Preprints. https://doi.org/10.20944/preprints202407.1461.v1
Chicago/Turabian Style
PLEBANI, M., Markus Herrmann and Mario Cozzolino. 2024 "Vitamin D Assay and Supplementation: Still Debatable Issues" Preprints. https://doi.org/10.20944/preprints202407.1461.v1
Abstract
Over the last decades, in addition to the improvement of pathophysiological knowledge regarding the role and mechanisms of action of Vitamin D, there has been a progressive advancement in analytical technologies for its determination, as well as in methodological standardization. A significant number of scientific works, meta-analyses, and guidelines have been published on the importance of Vitamin D and the need for supplementation in deficient individuals. However, it appears necessary to clarify the fundamental elements related to the determination of Vitamin D (both at the strictly analytical and post-analytical levels) and the scientific evidence related to the efficacy/safety of supplementation. Additionally, given the important interrelations between Vitamin D, parathyroid hormone (PTH), and fibroblast growth factor-23 (FGF23), the analytical issues and clinical utility of these biomarkers will be discussed.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
