PreprintReviewVersion 1This version is not peer-reviewed
Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-morbidity and Multi-treatment Patients Requiring Multi-drugs – a Narrative Review
Version 1
: Received: 18 July 2024 / Approved: 18 July 2024 / Online: 19 July 2024 (02:51:56 CEST)
How to cite:
Pludowski, P.; Marcinowska-Suchowierska, E.; Togizbayev, G.; Belaya, Z.; Grant, W. B.; Pilz, S.; Holick, M. F. Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-morbidity and Multi-treatment Patients Requiring Multi-drugs – a Narrative Review. Preprints2024, 2024071527. https://doi.org/10.20944/preprints202407.1527.v1
Pludowski, P.; Marcinowska-Suchowierska, E.; Togizbayev, G.; Belaya, Z.; Grant, W. B.; Pilz, S.; Holick, M. F. Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-morbidity and Multi-treatment Patients Requiring Multi-drugs – a Narrative Review. Preprints 2024, 2024071527. https://doi.org/10.20944/preprints202407.1527.v1
Pludowski, P.; Marcinowska-Suchowierska, E.; Togizbayev, G.; Belaya, Z.; Grant, W. B.; Pilz, S.; Holick, M. F. Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-morbidity and Multi-treatment Patients Requiring Multi-drugs – a Narrative Review. Preprints2024, 2024071527. https://doi.org/10.20944/preprints202407.1527.v1
APA Style
Pludowski, P., Marcinowska-Suchowierska, E., Togizbayev, G., Belaya, Z., Grant, W. B., Pilz, S., & Holick, M. F. (2024). Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-morbidity and Multi-treatment Patients Requiring Multi-drugs – a Narrative Review. Preprints. https://doi.org/10.20944/preprints202407.1527.v1
Chicago/Turabian Style
Pludowski, P., Stefan Pilz and Michael F. Holick. 2024 "Daily and Weekly “High Doses” of Cholecalciferol for the Prevention and Treatment of Vitamin D Deficiency for Obese or Multi-morbidity and Multi-treatment Patients Requiring Multi-drugs – a Narrative Review" Preprints. https://doi.org/10.20944/preprints202407.1527.v1
Abstract
Abstract. Daily vitamin D supplementation using higher than normal dosing (up to the upper limit, UL) and intermittent (once or twice per week) dosing were studied in patients with increased risk of vitamin D deficiency. Using a PubMed database an adequate search for published randomized control trials and other studies was done and results were analyzed. This review provides overview of use of 7000 IU daily, 30,000 IU per week or twice weekly and 50,000 IU weekly of vitamin D on rapid restore of 25(OH)D concentrations to at least 30 ng/mL in different groups of patients at high risk of vitamin D deficiency. The above mention dosing should be considered in adults with obesity or multi-diseased patients on requiring multi-treatment with the use of several drugs, including drugs affecting vitamin D metabolism. The simple schedule for 7000 IU/day, 30,000 IU/week or twice weekly or 50,000 IU/week, all for 6-8 weeks of use by patients representing the increased risk of vitamin D deficiency were provided for consideration. It appeared that higher daily doses or intermittent doses suggested above are effective, safe and responsive for patient’s preferences.
Keywords
vitamin D in high dose; 7,000 IU per day; 30,000 IU per week; 50,000 IU per week; effectiveness; safety; intermittent doses
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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