Version 1
: Received: 18 July 2024 / Approved: 18 July 2024 / Online: 18 July 2024 (23:44:57 CEST)
How to cite:
Schöbi, N.; Duppenthaler, A.; Horn, M.; Bartenstein, A.; Keitel, K.; Kopp, M. V.; Agyeman, P. K.; Aebi, C. Ongoing excess hospitalizations for severe pediatric Group A streptococcal disease in 2023-2024 – a single center report. Preprints2024, 2024071530. https://doi.org/10.20944/preprints202407.1530.v1
Schöbi, N.; Duppenthaler, A.; Horn, M.; Bartenstein, A.; Keitel, K.; Kopp, M. V.; Agyeman, P. K.; Aebi, C. Ongoing excess hospitalizations for severe pediatric Group A streptococcal disease in 2023-2024 – a single center report. Preprints 2024, 2024071530. https://doi.org/10.20944/preprints202407.1530.v1
Schöbi, N.; Duppenthaler, A.; Horn, M.; Bartenstein, A.; Keitel, K.; Kopp, M. V.; Agyeman, P. K.; Aebi, C. Ongoing excess hospitalizations for severe pediatric Group A streptococcal disease in 2023-2024 – a single center report. Preprints2024, 2024071530. https://doi.org/10.20944/preprints202407.1530.v1
APA Style
Schöbi, N., Duppenthaler, A., Horn, M., Bartenstein, A., Keitel, K., Kopp, M. V., Agyeman, P. K., & Aebi, C. (2024). Ongoing excess hospitalizations for severe pediatric Group A streptococcal disease in 2023-2024 – a single center report. Preprints. https://doi.org/10.20944/preprints202407.1530.v1
Chicago/Turabian Style
Schöbi, N., Philipp KA Agyeman and Christoph Aebi. 2024 "Ongoing excess hospitalizations for severe pediatric Group A streptococcal disease in 2023-2024 – a single center report" Preprints. https://doi.org/10.20944/preprints202407.1530.v1
Abstract
A Europe-wide outbreak of invasive pediatric Group a streptococcal infections (iGAS) began in fall 2022. Here we report the evolution of GAS hospitalizations in children and adolescents during the second outbreak year in 2023-2024 at a tertiary center in Switzerland. Using prospective monitoring of all in-patient GAS cases below 16 years of age including those with iGAS, we compared case frequencies and clinical characteristics in three time periods (2013-2020; 2022-2023; 2023-2024). Annual GAS hospitalizations increased from a median of 25 case (range 11-28) in 2013-2020 to 89 and 63 cases, respectively, in 2022-2023 and 2023-2024. iGAS cases evolved similarly (2013-2020, 4 cases (3-8); 2022-2023, 32 cases; 2023-2024, 21 cases). The decline in cases from 2022-2023 to 2023-2024 included all types of GAS organ involvement except suppurative infections in the head area, which remained largely unchanged (48 vs. 45 cases). Pleural empyema declined from 13 to 7 cases, possibly explained by a poor overlap of the GAS and influenza curves, respectively, in 2023-2024 compared to 2022-2023. These data document the prolongation of the GAS outbreak into its second winter season in 2023-2024, however with a decline of iGAS, pleural empyema, skin and soft tissue infection and infections of bone, joint and muscle.
Keywords
Streptococcus pyogenes; invasive Group A streptococcus; iGAS; child; outbreak; Influenza
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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