Preprint Article Version 1 This version is not peer-reviewed

Effectiveness of Hepatitis C Virus Self-Testing Service Delivery Models among People Who Inject Drugs: A Cross-Sectional Study in Vietnam

Version 1 : Received: 19 July 2024 / Approved: 19 July 2024 / Online: 19 July 2024 (15:19:23 CEST)

How to cite: Vu, B. N.; Green, K. E.; Tran, M. H.; Nguyen, H. M.; Do, K. T.; Nguyen, K. T.; Phan, H. T. T.; Tran, L. T. H.; Tran, A. K.; Le, G. T.; Pham, C. V.; Granger, K.; Nguyen, A. L. T.; Tran, L. K. Effectiveness of Hepatitis C Virus Self-Testing Service Delivery Models among People Who Inject Drugs: A Cross-Sectional Study in Vietnam. Preprints 2024, 2024071615. https://doi.org/10.20944/preprints202407.1615.v1 Vu, B. N.; Green, K. E.; Tran, M. H.; Nguyen, H. M.; Do, K. T.; Nguyen, K. T.; Phan, H. T. T.; Tran, L. T. H.; Tran, A. K.; Le, G. T.; Pham, C. V.; Granger, K.; Nguyen, A. L. T.; Tran, L. K. Effectiveness of Hepatitis C Virus Self-Testing Service Delivery Models among People Who Inject Drugs: A Cross-Sectional Study in Vietnam. Preprints 2024, 2024071615. https://doi.org/10.20944/preprints202407.1615.v1

Abstract

This study assesses the effectiveness of HCV self-testing (HCVST) distribution models compared to provider-led HCV testing (PL-HCVT), including the standard of care facility-based HCVT (SOC-HCVT) and community-based organization HCVT (CBO-HCVT) among people who inject drugs (PWID) in Vietnam. A cross-sectional study was conducted as part of a larger implementation science study in Hanoi and Ho Chi Minh City from September 2023 to April 2024. We engaged 8 CBOs and 10 public and private clinics in offering choice of HCVST through community-based and facility-based distribution, and secondary distribution), or PL-HCVT via SOC-HCVT and CBO-HCVT. Among 1,165 PWID, 693 opted for HCVST and 472 for PL-HCVT. The proportion of first-time testers was significantly higher in HIVST community-based and secondary distribution as well as CBO-HCVT compared to SOC-HCVT and facility-based HCVST (87.1%, 93.3% and 82.7% vs. 41.9% and 35.7%, respectively; p < 0.001). Overall, HCV seropositivity rate was lower in HCVST than PL-HCVT, however, higher in HCVST facility-based and community-based distribution compared to HCVST secondary distribution (28.1% and 20.4% vs. 5.7%, respectively). Community-based HCVST was most effective, followed by facility-based HCVST and secondary distribution. Our findings indicate that HCVST effectively reaches first-time testers and results in more people diagnosed and treated among PWID.

Keywords

HCV self-testing; people who inject drugs; effectiveness; service delivery; Vietnam

Subject

Public Health and Healthcare, Primary Health Care

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