PreprintArticleVersion 1This version is not peer-reviewed
Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction
Version 1
: Received: 19 July 2024 / Approved: 20 July 2024 / Online: 22 July 2024 (05:28:41 CEST)
How to cite:
Gouaref, I.; Makrelouf, M.; Otmane, A.; Ait Abderrhmane, S.; Ali El Mahdi, H.; Elhadj-Ahmed, K. Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction. Preprints2024, 2024071637. https://doi.org/10.20944/preprints202407.1637.v1
Gouaref, I.; Makrelouf, M.; Otmane, A.; Ait Abderrhmane, S.; Ali El Mahdi, H.; Elhadj-Ahmed, K. Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction. Preprints 2024, 2024071637. https://doi.org/10.20944/preprints202407.1637.v1
Gouaref, I.; Makrelouf, M.; Otmane, A.; Ait Abderrhmane, S.; Ali El Mahdi, H.; Elhadj-Ahmed, K. Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction. Preprints2024, 2024071637. https://doi.org/10.20944/preprints202407.1637.v1
APA Style
Gouaref, I., Makrelouf, M., Otmane, A., Ait Abderrhmane, S., Ali El Mahdi, H., & Elhadj-Ahmed, K. (2024). Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction. Preprints. https://doi.org/10.20944/preprints202407.1637.v1
Chicago/Turabian Style
Gouaref, I., Haddam Ali El Mahdi and Koceir Elhadj-Ahmed. 2024 "Crucial Interactions between Altered Plasma Trace Elements and Fatty Acids Unbalance Ratio to Management of Systemic Arterial Hypertension in Diabetic Patients: Focus on Endothelial Dysfunction" Preprints. https://doi.org/10.20944/preprints202407.1637.v1
Abstract
The coexistence of SAH with T2DM is a common comorbidity. In this present study, we investigated the link between altered plasma antioxidant trace elements (ATE: Manganese, Selenium, Zinc and Copper) and fatty acids ratio (FAR: polyunsaturated/saturated) imbalance as transition biomarkers between vascular pathology (SAH) to metabolic pathology (T2DM). Our data revealed strong correlation between plasma ATE and FAR profile which is modified during SAH-T2DM association compared to healthy group. This relationship is mediated by lipotoxicity (simultaneously prominent visceral adipose tissue lipolysis, significant flow of non-esterified free fatty acids release, TG-Chol-dyslipidemia, high association of Total SFA, Palmitic acid, Arachidonic acid and PUFA 6/ PUFA 3; drop in tandem of PUFA / SFA and EPA+DHA); oxidative stress (lipid peroxidation confirmed by TAS depletion and MDA raise, concurrently drop of Zn/Cu-SOD, GPx, GSH, Se, Zn, Se/Mn, Zn/Cu; concomitantly enhance Cu, Mn and Fe); endothelial dysfunction (endotheline-1 increase); athero-thrombogenesis risk (concomitantly raise of ApoB100/ApoA1, Ox-LDL, tHcy and Lp(a)) and inflammation (higher of Hs-CRP, Fibrinogen and Ferritin). Our study open to new therapeutic targets and to better dietary management, such as to establish dietary ATE and PUFA 6 / PUFA 3 or PUFA / SFA reference values for atherosclerotic risk prevention in hypertensive-diabetics patients.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
