CAR-T Cells in the Treatment of Nervous System Tumors

How to cite: Testa, U.; Castelli, G.; Pelosi, E. CAR-T Cells in the Treatment of Nervous System Tumors. Preprints 2024, 2024071661. https://doi.org/10.20944/preprints202407.1661.v1 Testa, U.; Castelli, G.; Pelosi, E. CAR-T Cells in the Treatment of Nervous System Tumors. Preprints 2024, 2024071661. https://doi.org/10.20944/preprints202407.1661.v1

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MDPI and ACS Style

Testa, U.; Castelli, G.; Pelosi, E. CAR-T Cells in the Treatment of Nervous System Tumors. Preprints 2024, 2024071661. https://doi.org/10.20944/preprints202407.1661.v1

APA Style

Testa, U., Castelli, G., & Pelosi, E. (2024). CAR-T Cells in the Treatment of Nervous System Tumors. Preprints. https://doi.org/10.20944/preprints202407.1661.v1

Chicago/Turabian Style

Testa, U., Germana Castelli and Elvira Pelosi. 2024 "CAR-T Cells in the Treatment of Nervous System Tumors" Preprints. https://doi.org/10.20944/preprints202407.1661.v1

Abstract

Chimeric antigen receptor T cells (CAR-Ts) have shown a remarkable efficacy in hematological malignancies, but limited responses in solid tumors. Among solid tumors, CAR-T cell therapy was particularly explored in brain tumors. CAR-T cells have shown a limited clinical efficacy in various types of brain tumors due to several factors that have hampered their activity, including tumor antigen heterogeneity (not all tumor cells express the target antigen), the limited access of CAR-T cells to brain tumor cells, limited CAR-T cell trafficking and in vivo persistence and the presence of a highly immunosuppressive tumor microenvironment. Despite these considerations, some recent studies have shown promising anti-tumor activity of GD2-CAR-T cells on diffuse midline gliomas and neuroblastomas and of CARv3-TEAM-E cells in glioblastomas. However, strategies are required to improve the effect of CAR-T cells in brain tumors, including advanced CAR-T cell design with multiple antigenic targeting and incorporation of combination therapies.

Keywords

Immunotherapy; Chimeric Antigen Receptor T-cells; Nervous System Tumors; Brain Tumors; Glioblastoma; Diffuse Midlime Glioma; Neuroblastoma

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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