Version 1
: Received: 20 July 2024 / Approved: 22 July 2024 / Online: 22 July 2024 (17:36:55 CEST)
How to cite:
Clemence, B. F.; Xiao, L.; Yang, G. Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel. Preprints2024, 2024071733. https://doi.org/10.20944/preprints202407.1733.v1
Clemence, B. F.; Xiao, L.; Yang, G. Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel. Preprints 2024, 2024071733. https://doi.org/10.20944/preprints202407.1733.v1
Clemence, B. F.; Xiao, L.; Yang, G. Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel. Preprints2024, 2024071733. https://doi.org/10.20944/preprints202407.1733.v1
APA Style
Clemence, B. F., Xiao, L., & Yang, G. (2024). Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel. Preprints. https://doi.org/10.20944/preprints202407.1733.v1
Chicago/Turabian Style
Clemence, B. F., Lin Xiao and Guang Yang. 2024 "Oral Administration of Berberine Hydrochloride Based on Chitosan/Carboxymethyl-β-Cyclodextrin Hydrogel" Preprints. https://doi.org/10.20944/preprints202407.1733.v1
Abstract
In this study, a novel oral formulation of berberine hydrochloride (BBH) hydrogel was successfully synthesized through physical cross-linking using chitosan (CS) and carboxymethyl-β-cyclodextrin (CMCD). The characterization results confirmed the successful synthesis of CS/CMCD hydrogel and the subsequent loading of BBH into this composite (CS/CMCD/BBH) was effectively accomplished. BBH was used as a model drug and the resulting hydrogel demonstrated a sustained drug release profile. In addition to its improved solubility and sustained release characteristics, the hydrogel exhibited excellent antibacterial activity against common pathogens such as Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans). Additionally, in vitro studies indicated that the hydrogel was not cytotoxic to NIH3T3 and HaCaT cells, suggesting its safety for biomedical applications. This lack of cytotoxic effects, combined with the mechanical strength, solubility improvements, and antibacterial properties of the hydrogel, positions the CS/CMCD/BBH hydrogel as a promising candidate for effective oral delivery of BBH. By addressing the solubility and delivery challenges of BBH, this hydrogel offers a viable solution for the oral administration of berberine hydrochloride, with potential applications in various biomedical fields.
Keywords
Berberine hydrochloride; Chitosan/Carboxymethyl-β-Cyclodextrin; Hydrogel formulation; Solubility enhancement; Oral drug delivery.
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
