Version 1
: Received: 22 July 2024 / Approved: 23 July 2024 / Online: 23 July 2024 (09:44:38 CEST)
How to cite:
de Lima-Pardini, A. C.; Nucci, M. P.; Neves de Oliveira, C.; Alho, E. J. L.; Coelho, D. B. Tractography Insights into Anticipatory Postural Adjustment and Freezing of Gait in Parkinson's Disease. Preprints2024, 2024071766. https://doi.org/10.20944/preprints202407.1766.v1
de Lima-Pardini, A. C.; Nucci, M. P.; Neves de Oliveira, C.; Alho, E. J. L.; Coelho, D. B. Tractography Insights into Anticipatory Postural Adjustment and Freezing of Gait in Parkinson's Disease. Preprints 2024, 2024071766. https://doi.org/10.20944/preprints202407.1766.v1
de Lima-Pardini, A. C.; Nucci, M. P.; Neves de Oliveira, C.; Alho, E. J. L.; Coelho, D. B. Tractography Insights into Anticipatory Postural Adjustment and Freezing of Gait in Parkinson's Disease. Preprints2024, 2024071766. https://doi.org/10.20944/preprints202407.1766.v1
APA Style
de Lima-Pardini, A. C., Nucci, M. P., Neves de Oliveira, C., Alho, E. J. L., & Coelho, D. B. (2024). Tractography Insights into Anticipatory Postural Adjustment and Freezing of Gait in Parkinson's Disease. Preprints. https://doi.org/10.20944/preprints202407.1766.v1
Chicago/Turabian Style
de Lima-Pardini, A. C., Eduardo Joaquim Lopes Alho and Daniel Boari Coelho. 2024 "Tractography Insights into Anticipatory Postural Adjustment and Freezing of Gait in Parkinson's Disease" Preprints. https://doi.org/10.20944/preprints202407.1766.v1
Abstract
Freezing of Gait (FoG) is a disabling motor complication in Parkinson’s disease (PD), affecting approximately 50% of advanced PD patients. It is characterized by sudden and transient inability to initiate or maintain walking, leading to falls and reduced quality of life. This study investigates the relationship between white matter integrity and step initiation impairments in FoG. Forty-three PD patients (26 with FoG) underwent diffusion-weighted imaging to assess white matter DTI metrics and kinematic analysis during step initiation tasks. Multiple regression analyses were conducted to explore the connection between white matter tract integrity and step initiation behavior. The multiple regression analysis shows that (1) Right Inferior Longitudinal Fasciculus RD explained 31% of APA duration’s variance; (2) Corpus Callosum Forceps Major explained 25% of the step length's variance. There was a positive correlation between the Right Inferior Longitudinal Fasciculus RD and APA duration and a negative correlation between Corpus Callosum Forceps Major RD and step length. The findings suggest that compromised white matter integrity in RILF and CC contributes to impaired motor control during step initiation in FoG. These regions are critical for inhibitory control and interhemispheric coordination, crucial for APA execution and step length regulation.
Keywords
movement disorders; step initiation; white matter integrity; diffusion tensor imaging
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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