Version 1
: Received: 24 July 2024 / Approved: 24 July 2024 / Online: 25 July 2024 (11:04:01 CEST)
How to cite:
Soares, D. J.; McCarthy, A. D. The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers Within an Artificial Model of Arterial Embolism. Preprints2024, 2024071979. https://doi.org/10.20944/preprints202407.1979.v1
Soares, D. J.; McCarthy, A. D. The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers Within an Artificial Model of Arterial Embolism. Preprints 2024, 2024071979. https://doi.org/10.20944/preprints202407.1979.v1
Soares, D. J.; McCarthy, A. D. The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers Within an Artificial Model of Arterial Embolism. Preprints2024, 2024071979. https://doi.org/10.20944/preprints202407.1979.v1
APA Style
Soares, D. J., & McCarthy, A. D. (2024). The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers Within an Artificial Model of Arterial Embolism. Preprints. https://doi.org/10.20944/preprints202407.1979.v1
Chicago/Turabian Style
Soares, D. J. and Alec D McCarthy. 2024 "The Impact of Gel Parameters on the Dispersal and Fragmentation of Hyaluronic Acid Gel Fillers Within an Artificial Model of Arterial Embolism" Preprints. https://doi.org/10.20944/preprints202407.1979.v1
Abstract
Accidental arterial embolization of hyaluronic acid (HA) fillers can lead to severe complications, including skin ischemia, blindness, and stroke. Currently, the intra-arterial dispersal and fragmentation behavior of HA gels is unknown but is critical to our understanding of the pathomechanism of these injuries. This work introduces the Pulsatile Unit for the Laboratory Simulation of Arterioembolic Restrictions (PULSAR) and evaluates the intravascular behavior of different HA gels. The fragmentation and dispersal behaviors of four HA gels with distinct rheological properties were evaluated via high-resolution videography and ImageJ particle size and morphology analysis. The gels' elastic modulus (G'), loss modulus (G''), tan(δ), and HA concentration were subsequently correlated with their intra-arterial behaviors. This study effectively confirms the extensive fragmentation of HA gels upon arterial inoculation, with particle sizes ranging from <50 µm to >1 mm. Gel particle size and morphology correlate most significantly with tan(δ). Conversely, arterial flow rates do not significantly influence gel fragmentation behavior, though the probability of proximal, macrovascular obstruction is affected. Overall, this study validates the PULSAR model for simulation of arterial dynamics and the testing of intravascular filler kinematics. The findings highlight the importance of gel viscoelasticity and flow parameters in determining particle size, dispersibility, and occlusive potential.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
