Version 1
: Received: 25 July 2024 / Approved: 26 July 2024 / Online: 26 July 2024 (12:55:27 CEST)
How to cite:
Alenezi, S. A.; Elkmeshi, N.; Alanazi, A.; Alanazi, S. T.; Khan, R.; Amer, S. The Impact of Diet-Induced Weight Loss on the Inflammatory Status and Hyperandrogenism in Women With PCOS – A Systematic Review and Meta-Analysis. Preprints2024, 2024072141. https://doi.org/10.20944/preprints202407.2141.v1
Alenezi, S. A.; Elkmeshi, N.; Alanazi, A.; Alanazi, S. T.; Khan, R.; Amer, S. The Impact of Diet-Induced Weight Loss on the Inflammatory Status and Hyperandrogenism in Women With PCOS – A Systematic Review and Meta-Analysis. Preprints 2024, 2024072141. https://doi.org/10.20944/preprints202407.2141.v1
Alenezi, S. A.; Elkmeshi, N.; Alanazi, A.; Alanazi, S. T.; Khan, R.; Amer, S. The Impact of Diet-Induced Weight Loss on the Inflammatory Status and Hyperandrogenism in Women With PCOS – A Systematic Review and Meta-Analysis. Preprints2024, 2024072141. https://doi.org/10.20944/preprints202407.2141.v1
APA Style
Alenezi, S. A., Elkmeshi, N., Alanazi, A., Alanazi, S. T., Khan, R., & Amer, S. (2024). The Impact of Diet-Induced Weight Loss on the Inflammatory Status and Hyperandrogenism in Women With PCOS – A Systematic Review and Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202407.2141.v1
Chicago/Turabian Style
Alenezi, S. A., Raheela Khan and Saad Amer. 2024 "The Impact of Diet-Induced Weight Loss on the Inflammatory Status and Hyperandrogenism in Women With PCOS – A Systematic Review and Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202407.2141.v1
Abstract
Currently, the primary strategy for addressing polycystic ovarian syndrome (PCOS) involves lifestyle modifications, with a focus on weight loss. The purpose of this meta-analysis was to assess the impact of weight loss through dietary interventions on inflammatory status and hyperandrogenism in PCOS women. A comprehensive search was conducted to identify randomised controlled trials (RCTs) and cohort studies assessing the impact of diet-induced weight loss on circulating inflammatory markers (CRP, IL-6, IL-1β, TNF-α), androgens (testosterone, SHBG, androstenedione) and luteinising hormone (LH) in PCOS women. The quality and risk of bias of the included studies were assessed using the Cochrane Collaboration's tool for RCTs and the Newcastle–Ottawa Scale for cohort studies. Data were entered into RevMan software v5.9 for the calculation of standard mean difference (SMD) and 95% confidence interval (95%CI) of circulating inflammatory markers, androgens and LH between baseline and post-weight loss values. Eleven studies (n=323) were eligible for the systematic review, of which nine (n=286) were included in the meta-analysis. Pooled analysis of data revealed a statistically significant decrease in circulating CRP (SMD 0.39, 95%CI 0.22, 0.56; 9 studies, n=286), IL-6 (SMD 0.37, 95%Cl, 0.12, 0.61; 3 Studies, n=140), TNF- α (SMD 0.30, 95%Cl, 0.07, 0.53; 4 Studies, n=162), androstenedione (SMD 0.36, 95%Cl, 0.13, 0.60; 4 studies, n=147) and LH (SMD 0.30, 95% Cl, 0.09, 0.51; 5 studies, n=197) after weight loss compared to baseline levels among PCOS women. Meta-analysis of five studies (n=173) showed a statistically significant increase in circulating SHBG after weight loss compared to baseline levels (SMD -0.43, 95%Cl, -0.65, -0.21). These findings suggest that weight loss induced by dietary interventions seems to improve PCOS-related chronic inflammation and hyperandrogenism. The possible causative relationship between the improvement in inflammation and hyperandrogenism remains to be determined.
Keywords
PCOS; chronic inflammation; hyperandrogenism; CRP; Obesity; weight loss
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
