Version 1
: Received: 26 July 2024 / Approved: 26 July 2024 / Online: 26 July 2024 (10:23:46 CEST)
How to cite:
Monzani, A.; Marcolin, S.; Medina, F.; Valentino, K.; Rabbone, I. BMI Status of Children with Celiac Disease Has Changed in the Last Decades: A 30-Year Retrospective Study. Preprints2024, 2024072150. https://doi.org/10.20944/preprints202407.2150.v1
Monzani, A.; Marcolin, S.; Medina, F.; Valentino, K.; Rabbone, I. BMI Status of Children with Celiac Disease Has Changed in the Last Decades: A 30-Year Retrospective Study. Preprints 2024, 2024072150. https://doi.org/10.20944/preprints202407.2150.v1
Monzani, A.; Marcolin, S.; Medina, F.; Valentino, K.; Rabbone, I. BMI Status of Children with Celiac Disease Has Changed in the Last Decades: A 30-Year Retrospective Study. Preprints2024, 2024072150. https://doi.org/10.20944/preprints202407.2150.v1
APA Style
Monzani, A., Marcolin, S., Medina, F., Valentino, K., & Rabbone, I. (2024). BMI Status of Children with Celiac Disease Has Changed in the Last Decades: A 30-Year Retrospective Study. Preprints. https://doi.org/10.20944/preprints202407.2150.v1
Chicago/Turabian Style
Monzani, A., Kevin Valentino and Ivana Rabbone. 2024 "BMI Status of Children with Celiac Disease Has Changed in the Last Decades: A 30-Year Retrospective Study" Preprints. https://doi.org/10.20944/preprints202407.2150.v1
Abstract
The presenting pattern of celiac disease (CD) at diagnosis in children has changed over time, with a reduction of malabsorption-related phenotypes and an increase in regular or even excessive growth patterns. We retrospectively reviewed the body mass index (BMI) distribution of all patients with a new diagnosis of CD made in a Pediatric Gastroenterology Outpatient Clinic in 1990-2011, compared to those diagnosed in 2012-2022, according to their clinical and serological characteristics. The 1990-2011 and 2012-2022 cohorts included 250 (M:F=90:160, mean age 7.3±6.1 years) and 243 children (M:F=81:162, mean age 7.1±3.7 years, NS), respectively. The prevalence of underweight (UW) was higher in the 1990-2011 cohort (61/250, 24.4% in 1990-2011 vs. 31/243, 12.7% in 2012-2022, p=0.0001), whereas that of overweight (OW) and obese (OB) subjects was significantly higher in 2012-2022 (10/250, 4% in 1990-2011 vs. 24/243, 9.9% in 2012-2022, p=0.012, and 1/250, 0.4% in 1990-2011 vs 8/243, 3.3% in 2012-2022, p=0.018, respectively). In both cohorts, gastrointestinal symptoms were more frequent in OW/OB than in UW children (6/11, 54.5% vs. 5/61, 8.2% in 1990-2011, p<0.0001, and 24/32, 75% vs. 10/31, 32.3%, p<0.0001 in 2012-2022) and the extent of anti-transglutaminase antibodies increase was similar in OW/OB and UW subjects. The prevalence of children with a normal or even high BMI at CD diagnosis has increased in the past three decades, therefore CD should be suspected regardless of the BMI status.
Keywords
celiac disease; children; body mass index; clinical presentation
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
