Review of the Role of Mitochondria in the Actions of Nitroglycerin and Redox Disturbances Underlying Diseases It Treats

Wayne Kaesemeyer MD

doi:10.20944/preprints202407.2331.v1

Preprint Review Version 1 This version is not peer-reviewed

Version 1 : Received: 27 July 2024 / Approved: 29 July 2024 / Online: 29 July 2024 (15:06:08 CEST)

ABSTRACT The purpose of this paper is to review the involvement of mitochondria in the actions of nitroglycerin (glycerol trinitrate -GTN) and the redox disturbances underlying diseases it treats. The paper begins by explaining complex I as the initial site of formation of superoxide and the process whereby it leads to the development of glutathione dependent tolerance. Next, the paper describes new formulations for preventing tolerance. The paper ends by illustrating diseases that may benefit from treatment with novel glutathione based GTN formulations and treatment approaches.

Key words: nitroglycerin; glutathione; mitochondria; complex I; eNOS; nitric oxide; S-nitrosylation; S-glutathiolation; superoxide; acute heart failure; right heart failure; diuretic resistance; refractory angina; NLRP3 inflammasome.

Medicine and Pharmacology, Cardiac and Cardiovascular Systems

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Review of the Role of Mitochondria in the Actions of Nitroglycerin and Redox Disturbances Underlying Diseases It Treats

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