Version 1
: Received: 27 July 2024 / Approved: 29 July 2024 / Online: 30 July 2024 (07:45:23 CEST)
How to cite:
Cheung, H.; Kang, H.; Lee, H. J.; Chung, Y.; Shin, H.; Lee, S.; Kim, J.-H. Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin. Preprints2024, 2024072353. https://doi.org/10.20944/preprints202407.2353.v1
Cheung, H.; Kang, H.; Lee, H. J.; Chung, Y.; Shin, H.; Lee, S.; Kim, J.-H. Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin. Preprints 2024, 2024072353. https://doi.org/10.20944/preprints202407.2353.v1
Cheung, H.; Kang, H.; Lee, H. J.; Chung, Y.; Shin, H.; Lee, S.; Kim, J.-H. Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin. Preprints2024, 2024072353. https://doi.org/10.20944/preprints202407.2353.v1
APA Style
Cheung, H., Kang, H., Lee, H. J., Chung, Y., Shin, H., Lee, S., & Kim, J. H. (2024). Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin. Preprints. https://doi.org/10.20944/preprints202407.2353.v1
Chicago/Turabian Style
Cheung, H., Sangmin Lee and Jong-Ho Kim. 2024 "Homologous Targeting Effect of Cancer Cell-Derived Liposomes (Memposomes) Mediated by Cell Adhesion Molecules: Role of E-cadherin" Preprints. https://doi.org/10.20944/preprints202407.2353.v1
Abstract
Cell membrane-derived liposomes, termed Memposomes, serve as promising carriers for drug delivery due to their ability to closely mimic cells and efficiently target specific cells. Liposomes derived from cancer cell membranes, in particular, exhibit homologous targeting capabilities, making them potential candidates for cancer-specific drug delivery. However, the underlying mechanisms and specific proteins responsible for this homologous targeting phenomenon remain debated. This study focuses on the role of E-cadherin, a cell adhesion molecule implicated in homophilic adhesion, in influencing the homologous targeting ability of Memposomes derived from cancer cell membranes. E-cadherin expression patterns were assessed in various cell lines, categorizing them into E-cadherin-positive and -negative groups. Memposomes were produced for each group, and their targeting tendencies were evaluated. The study confirmed that E-cadherin expression significantly influenced the homologous targeting ability of Memposomes. Cell lines with higher E-cadherin expression levels exhibited a more pronounced homologous targeting effect. This research demonstrates that cell adhesion molecules, particularly E-cadherin involved in homophilic adhesion, play a pivotal role in influencing the cell targeting ability of Memposomes. The study further validates the stability, safety, and purity of Memposomes, emphasizing their potential as effective drug delivery vehicles for the development of cell-specific therapies.
Keywords
cell membrane-derived liposomes; Memposomes; drug delivery vehicle; homologous targeting; E-cadherin
Subject
Chemistry and Materials Science, Biomaterials
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
