Version 1
: Received: 29 July 2024 / Approved: 30 July 2024 / Online: 30 July 2024 (10:26:17 CEST)
How to cite:
MORA-CABELLO, R.; FUENTES-RIOS, D.; GAGO, L.; CABEZA, L.; Moscoso, A.; Melguizo, C.; Prados, J.; Sarabia, F.; LOPEZ-ROMERO, J. M. Magnetic nanoparticles with on-site azide and alkyne functionalized polymer coating in a single step through a solvothermal process. Preprints2024, 2024072363. https://doi.org/10.20944/preprints202407.2363.v1
MORA-CABELLO, R.; FUENTES-RIOS, D.; GAGO, L.; CABEZA, L.; Moscoso, A.; Melguizo, C.; Prados, J.; Sarabia, F.; LOPEZ-ROMERO, J. M. Magnetic nanoparticles with on-site azide and alkyne functionalized polymer coating in a single step through a solvothermal process. Preprints 2024, 2024072363. https://doi.org/10.20944/preprints202407.2363.v1
MORA-CABELLO, R.; FUENTES-RIOS, D.; GAGO, L.; CABEZA, L.; Moscoso, A.; Melguizo, C.; Prados, J.; Sarabia, F.; LOPEZ-ROMERO, J. M. Magnetic nanoparticles with on-site azide and alkyne functionalized polymer coating in a single step through a solvothermal process. Preprints2024, 2024072363. https://doi.org/10.20944/preprints202407.2363.v1
APA Style
MORA-CABELLO, R., FUENTES-RIOS, D., GAGO, L., CABEZA, L., Moscoso, A., Melguizo, C., Prados, J., Sarabia, F., & LOPEZ-ROMERO, J. M. (2024). Magnetic nanoparticles with on-site azide and alkyne functionalized polymer coating in a single step through a solvothermal process. Preprints. https://doi.org/10.20944/preprints202407.2363.v1
Chicago/Turabian Style
MORA-CABELLO, R., Francisco Sarabia and JUAN MANUEL LOPEZ-ROMERO. 2024 "Magnetic nanoparticles with on-site azide and alkyne functionalized polymer coating in a single step through a solvothermal process" Preprints. https://doi.org/10.20944/preprints202407.2363.v1
Abstract
Magnetic Fe3O4 nanoparticles (MNPs) are becoming more important every day in drug targeting. We prepared here MNPs in a simple one-step reaction by following the solvothermal method assisted by azide and alkyne functionalized polyethylene glycol (PEG400) polymers, as well as by PEG6000 and the polyol -cyclodextrin (CD). The composition, morphology, and structure of the nanospheres were characterized using Transmission Electron Microscopy (TEM), Nuclear Magnetic Resonance (NMR), X-Ray Diffraction Diffractometry (XRD), Atomic Force Microscopy (AFM), Fourier-Transform Infrared Spectroscopy (FT-IR), Matrix-Assisted Laser Desorption/Ionization (MALDI) and Vibrating Sample Magnetometry (VSM). The obtained nanoparticles (@Fe3O4-PEGs and @Fe3O4-CD) showed diameters between 90-250 nm, depending on the polymer used and the Fe3O4·6H2O precursor concentration, typically, 0.13 M, 200 °C, and 24 h of reaction. MNPs exhibited superparamagnetic properties with high saturation of magnetization at room temperature, reaching values of 59.9 emu/g (@Fe3O4-PEG6000), and no ferromagnetism. Likewise, they showed temperature elevation after applying an alternating magnetic field (AMF) in all cases, obtaining Specific Absorption Rate (SAR) values of up to 51.87 ± 2.23 W/g in the case of @Fe3O4-PEG6000. Both PEGs and the βCD played a crucial role as electrostatic stabilizers in the formation of Fe3O4 nanospheres, providing a polymeric/polyol coating around the magnetic cores. Additionally, the formed systems are susceptible for click chemistry, as was demonstrated in the case of the cannabidiol-propargyl derivative (CBD-Pro), which was synthesized and covalently attached to the azide functionalized surface of the system @Fe3O4-PEG400-N3. Prepared MNPs are highly dispersible in water, remaining in suspension for over 3 days, and non-toxic in the T84 human colon cancer cell line, indicating that they are ideal candidates for biomedical applications.
Chemistry and Materials Science, Surfaces, Coatings and Films
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
