Version 1
: Received: 28 July 2024 / Approved: 30 July 2024 / Online: 30 July 2024 (11:03:41 CEST)
How to cite:
Bollen, I.; Bernhardt, M.; Thiesler, T.; Winterhagen, F. I.; Türler, A.; Ritter, M.; Mustea, A.; Kristiansen, G. The Prognostic Value of Adipokines LeptinR And AdiponectinR1 in Obesity-inducible Solid Tumours. Preprints2024, 2024072385. https://doi.org/10.20944/preprints202407.2385.v1
Bollen, I.; Bernhardt, M.; Thiesler, T.; Winterhagen, F. I.; Türler, A.; Ritter, M.; Mustea, A.; Kristiansen, G. The Prognostic Value of Adipokines LeptinR And AdiponectinR1 in Obesity-inducible Solid Tumours. Preprints 2024, 2024072385. https://doi.org/10.20944/preprints202407.2385.v1
Bollen, I.; Bernhardt, M.; Thiesler, T.; Winterhagen, F. I.; Türler, A.; Ritter, M.; Mustea, A.; Kristiansen, G. The Prognostic Value of Adipokines LeptinR And AdiponectinR1 in Obesity-inducible Solid Tumours. Preprints2024, 2024072385. https://doi.org/10.20944/preprints202407.2385.v1
APA Style
Bollen, I., Bernhardt, M., Thiesler, T., Winterhagen, F. I., Türler, A., Ritter, M., Mustea, A., & Kristiansen, G. (2024). The Prognostic Value of Adipokines LeptinR And AdiponectinR1 in Obesity-inducible Solid Tumours. Preprints. https://doi.org/10.20944/preprints202407.2385.v1
Chicago/Turabian Style
Bollen, I., Alexander Mustea and Glen Kristiansen. 2024 "The Prognostic Value of Adipokines LeptinR And AdiponectinR1 in Obesity-inducible Solid Tumours" Preprints. https://doi.org/10.20944/preprints202407.2385.v1
Abstract
(1) Background: With the rising incidence of life expectancy, obesity, and tumours, understanding the incretory influence of adipose tissue in tumorigenesis becomes increasingly important. As the adipokines leptin and adiponectin are released by fat tissue, we aimed to analyse the expression of their respective receptors in tumours for which an association with obesity is epidemiologically hypothesized; (2) Methods: The expression of leptinR and adipoR1 were analysed in cohorts of renal cell cancer (n = 391), cervical cancer (n = 155), vulvar cancer (n = 107), and endometrial cancer (n = 90) by immunohistochemistry and correlated with clinicopathological parameters including survival times; (3) Results: Expression of leptinR was high in renal cell cancer (62.2% of cases), vulvar carcinoma (50%) and endometrial cancer (80.5% of tissue-samples). High expression was associated with favourable clinicopathological markers and longer overall survival times in renal cell cancer and vulvar cancer. AdipoR1 was only weakly expressed in all four tumor entities and did not show significant associations with clinicopathological parameters or prognosis; (4) Conclusion: High leptinR is a promising biomarker for favourable tumour outcome in renal cell carcinoma and vulvar carcinoma.
Keywords
Adipokine receptors; obesity related tumours; leptinR; adipoR1
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
