Article
Version 1
This version is not peer-reviewed
Alcohol Consumption and Cancer Risk: Two Sample Mendelian Randomization
Version 1
: Received: 29 July 2024 / Approved: 30 July 2024 / Online: 30 July 2024 (09:12:10 CEST)
How to cite: Jee, Y.; Ryu, M.; Sull, J. W. Alcohol Consumption and Cancer Risk: Two Sample Mendelian Randomization. Preprints 2024, 2024072438. https://doi.org/10.20944/preprints202407.2438.v1 Jee, Y.; Ryu, M.; Sull, J. W. Alcohol Consumption and Cancer Risk: Two Sample Mendelian Randomization. Preprints 2024, 2024072438. https://doi.org/10.20944/preprints202407.2438.v1
Abstract
Although numerous observational studies reported the association between alcohol consumption and cancer, insufficient studies have estimated the causality. Our study evaluated the causal relationship between various type of cancer according to the frequency of drinking and the amount of alcohol consumed. The research data were obtained from the publicly available MR-Base platform. The frequency and amount of drinking were selected as exposure, and 14 cancer types were selected as the outcome. Two-sample summary data Mendelian randomization (2SMR) was conducted to examine the causality between alcohol consumption and cancer type. Additionally, for cancers suspected of pleiotropy, outliers were removed and re-analyzed through radial MR. MR results by Inverse Variance Weighted (IVW) method were different before and after removing outliers. The biggest differences were found in esophageal cancer and biliary tract cancer. For esophageal cancer, after removing outliers (rs13102973, rs540606, rs650558), the OR (95% CI) was 3.44 (1.19-9.89), which was statistically significant (p=0.02172). Even in biliary tract cancer, after removing outliers (rs13231886, rs58905411), the OR (95% CI) was 3.86 (0.89-16.859), which was statistically significant at the borderline. (p=0.07223). The strongest association was shown in esophageal cancer. For other cancers, the evidence was not sufficient to draw conclusions. More research is needed to understand the causality between drinking and cancer.
Keywords
Alcohol consumption; causality; Mendelian randomization; cancer
Subject
Public Health and Healthcare, Public Health and Health Services
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
