Preprint Review Version 1 This version is not peer-reviewed

Nano-Formulations of Natural Antioxidants for the Treatment of Liver Cancer

Version 1 : Received: 30 July 2024 / Approved: 31 July 2024 / Online: 31 July 2024 (14:02:17 CEST)

How to cite: Cristani, M.; Citarella, A.; Carnamucio, F.; Micale, N. Nano-Formulations of Natural Antioxidants for the Treatment of Liver Cancer. Preprints 2024, 2024072544. https://doi.org/10.20944/preprints202407.2544.v1 Cristani, M.; Citarella, A.; Carnamucio, F.; Micale, N. Nano-Formulations of Natural Antioxidants for the Treatment of Liver Cancer. Preprints 2024, 2024072544. https://doi.org/10.20944/preprints202407.2544.v1

Abstract

Oxidative stress plays an essential role in the pathological processes that trigger various chronic liver diseases and contributes to the development of hepatocarcinogenesis. Antioxidants from natural sources trap free radicals by converting them into non-harmful products and minimize oxidative stress, playing a crucial function in the treatment of free radical-induced diseases. However, the activity of these antioxidants is limited due their poor bioavailability, which is why various nano-drug delivery systems have been developed to improve their stability, promote smooth release, and targeted delivery for liver cancer treatment. Specifically, this review aims to report recent scientific findings of novel nano-formulations containing natural antioxidant molecules targeted for the treatment of liver cancer.

Keywords

antioxidants; liver cancer; nano-formulations; drug delivery; natural compounds; hepatocellular carcinoma; oxidative stress

Subject

Chemistry and Materials Science, Medicinal Chemistry

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