PreprintArticleVersion 1This version is not peer-reviewed
Peripancreatic Head Paraganglioma Versus Neuroendocrine Tumor, a Roller Coaster Diagnostic Dilemma in Fine Needle Aspiration Cytology with a Note: “A Definite Diagnosis Cannot Be Concluded”
Version 1
: Received: 28 July 2024 / Approved: 31 July 2024 / Online: 31 July 2024 (11:38:28 CEST)
How to cite:
Niaz, Z.; Ismail, B.; Al Farai, A. Y.; Telugu, R. B.; Al Haddabi, I. H. Peripancreatic Head Paraganglioma Versus Neuroendocrine Tumor, a Roller Coaster Diagnostic Dilemma in Fine Needle Aspiration Cytology with a Note: “A Definite Diagnosis Cannot Be Concluded”. Preprints2024, 2024072567. https://doi.org/10.20944/preprints202407.2567.v1
Niaz, Z.; Ismail, B.; Al Farai, A. Y.; Telugu, R. B.; Al Haddabi, I. H. Peripancreatic Head Paraganglioma Versus Neuroendocrine Tumor, a Roller Coaster Diagnostic Dilemma in Fine Needle Aspiration Cytology with a Note: “A Definite Diagnosis Cannot Be Concluded”. Preprints 2024, 2024072567. https://doi.org/10.20944/preprints202407.2567.v1
Niaz, Z.; Ismail, B.; Al Farai, A. Y.; Telugu, R. B.; Al Haddabi, I. H. Peripancreatic Head Paraganglioma Versus Neuroendocrine Tumor, a Roller Coaster Diagnostic Dilemma in Fine Needle Aspiration Cytology with a Note: “A Definite Diagnosis Cannot Be Concluded”. Preprints2024, 2024072567. https://doi.org/10.20944/preprints202407.2567.v1
APA Style
Niaz, Z., Ismail, B., Al Farai, A. Y., Telugu, R. B., & Al Haddabi, I. H. (2024). Peripancreatic Head Paraganglioma Versus Neuroendocrine Tumor, a Roller Coaster Diagnostic Dilemma in Fine Needle Aspiration Cytology with a Note: “A Definite Diagnosis Cannot Be Concluded”. Preprints. https://doi.org/10.20944/preprints202407.2567.v1
Chicago/Turabian Style
Niaz, Z., Ramesh Babu Telugu and Ibrahim Hassan Al Haddabi. 2024 "Peripancreatic Head Paraganglioma Versus Neuroendocrine Tumor, a Roller Coaster Diagnostic Dilemma in Fine Needle Aspiration Cytology with a Note: “A Definite Diagnosis Cannot Be Concluded”" Preprints. https://doi.org/10.20944/preprints202407.2567.v1
Abstract
Cytologic diagnosis of extra‐adrenal paraganglioma presenting as a peripancreatic mass is challenging with a high rate of diagnostic error. We present a case of a peripancreatic mass identified by radiology as a gastrointestinal stromal tumor. Endoscopic ultrasound‐guided fine needle aspiration (FNA) of the mass showed a moderately cellular tumor composed of small to medium sized neoplastic cells with round to oval nuclei arranged singly and in loose clusters. The cells were positive for neuroendocrine markers (synaptophysin and chromogranin) and negative for CD117. A diagnosis of a neoplasm with a neuroendocrine tumor (NET) was made on FNA cytology. The subsequent surgical resection of the tumor revealed peripancreatic paraganglioma with immunohistochemistry positive for synaptophysin, chromogranin, and S100. The latter delineates the sustentacular cells. Although paraganglioma is a well recognized tumor, a detailed comparison of peripancreatic paraganglioma versus pancreatic/gastrointestinal NET is still lacking.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
